Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL3307199 | 0.97 | CYP3A4 (0.87) | — | |
| Choline SCHEMBL29499824 | 0.96 | — | — | |
| Choline SCHEMBL2459999 | 0.96 | CYP3A4 (1.00) | — | |
| Choline SCHEMBL28574484 | 0.96 | CYP3A4 (1.00) | — | |
| Choline SCHEMBL1330530 | 0.96 | — | — | |
| Choline SCHEMBL9391204 | 0.96 | CYP3A4 (1.00) | — | |
| Choline SCHEMBL30612764 | 0.96 | — | — | |
| Choline SCHEMBL1332010 | 0.96 | — | — | |
| Choline SCHEMBL14957 | 0.96 | — | — | |
| Choline SCHEMBL1615528 | 0.96 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658361-A1 | LIQUID DISH CLEANING COMPOSITIONS | Colgate-Palmolive Company (US) | 2006-05-24 | — | — | EP | claimed |
| WO-2005021698-A1 | LIQUID DISH CLEANING COMPOSITIONS | COLGATE-PALMOLIVE COMPANY (US) | 2005-03-10 | — | — | WO | claimed |
| US-20050049161-A1 | LIQUID DISH CLEANING COMPOSITIONS | COLGATE-PALMOLIVE COMPANY | 2005-03-03 | — | — | US | claimed |
| EP-1485455-A1 | FOAMSTABLE ANTIMICROBIAL LIQUID DISH CLEANING COMPOSITIONS | Colgate-Palmolive Company (US) | 2004-12-15 | — | — | EP | claimed |
| EP-1485454-A1 | ANTIBACTERIAL LIQUID DISH CLEANING COMPOSITIONS | Colgate-Palmolive Company (US) | 2004-12-15 | — | — | EP | claimed |
| EP-1485457-A1 | ANTIBACTERIAL LIQUID DISH CLEANING COMPOSITIONS | Colgate-Palmolive Company (US) | 2004-12-15 | — | — | EP | claimed |
| US-20040101504-A1 | Mild antibacterial liquid dish cleaning composition having improved stability | COLGATE-PALMOLIVE COMPANY | 2004-05-27 | — | — | US | claimed |
| WO-2003080783-A1 | ANTIBACTERIAL LIQUID DISH CLEANING COMPOSITIONS | COLGATE-PALMOLIVE COMPANY (US) | 2003-10-02 | — | — | WO | claimed |
| WO-2003080784-A1 | FOAMSTABLE ANTIMICROBIAL LIQUID DISH CLEANING COMPOSITIONS | COLGATE-PALMOLIVE COMPANY (US) | 2003-10-02 | — | — | WO | claimed |
| WO-2003080786-A1 | ANTIBACTERIAL LIQUID DISH CLEANING COMPOSITIONS | COLGATE-PALMOLIVE COMPANY (US) | 2003-10-02 | — | — | WO | claimed |
| US-20030144218-A1 | Mild antibacterial liquid dish cleaning compositions having improved stability | COLGATE-PALMOLIVE COMPANY | 2003-07-31 | — | — | US | claimed |
| US-20030144170-A1 | Antibacterial liquid dish cleaning compositions | COLGATE-PALMOLIVE COMPANY | 2003-07-31 | — | — | US | claimed |
| US-20020197293-A1 | Antibacterial liquid dish cleaning compositions having improved viscosity | COLGATE-PALMOLIVE COMPANY | 2002-12-26 | — | — | US | claimed |
| US-20020198130-A1 | Antibacterial liquid dish cleaning compositions | COLGATE-PALMOLIVE COMPANY | 2002-12-26 | — | — | US | claimed |
| WO-2002092743-A1 | ANTIBACTERIAL LIQUID DISH CLEANING COMPOSITIONS HAVING IMPROVED VISCOSITY | COLGATE-PALMOLIVE COMPANY (US) | 2002-11-21 | — | — | WO | claimed |
| CN-113461975-A | Choline chloride eutectic solvent and preparation method and application thereof | 江苏大学 | 2021-10-01 | — | — | CN | disclosed |
| EP-2429316-B1 | PROCESS TO PREPARE A LOW-SODIUM SALT PRODUCT, PRODUCT OBTAINABLE THEREBY AND THE USE THEREOF | AKZO NOBEL CHEMICALS INT BV (NL) | 2016-05-25 | — | — | EP | disclosed |
| EP-1658361-A1 | LIQUID DISH CLEANING COMPOSITIONS | Colgate-Palmolive Company (US) | 2006-05-24 | — | — | EP | disclosed |
| WO-2005021698-A1 | LIQUID DISH CLEANING COMPOSITIONS | COLGATE-PALMOLIVE COMPANY (US) | 2005-03-10 | — | — | WO | disclosed |