SCHEMBL33098

SCHEMBL33098

C=C(OCCCC)c1ccc2c(c1)CCC2=O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 4/20 0.43
HSD17B1 P14061 2/20 0.42
BRD4 O60885 1/20 0.42
HRH3 Q9Y5N1 3/20 0.41
MEN1 O00255 1/20 0.39
ALDH1A1 P00352 1/20 0.39
KMT2A Q03164 1/20 0.39
CASP1 P29466 1/20 0.39
CASP7 P55210 1/20 0.39
HSD17B10 Q99714 1/20 0.39
ESR1 P03372 3/20 0.38
LMNA P02545 2/20 0.38
CYP1A2 P05177 2/20 0.38
TSHR P16473 2/20 0.38
CYP2C19 P33261 2/20 0.38
CYP2D6 P10635 1/20 0.38
MAPK1 P28482 1/20 0.38
NR1H2 P55055 1/20 0.38
RNASEL Q05823 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL38659727 0.85 ALDH1A1 (0.54) BRD4MEN1ALDH1A1KMT2AESR1
SCHEMBL2653935 0.85 ALDH1A1 (0.54) BRD4MEN1ALDH1A1KMT2AESR1
SCHEMBL19770242 0.80 PRF1 (0.47) MAOBMEN1ALDH1A1KMT2AHSD17B10
SCHEMBL17332142 0.79 MAOB (0.34) MAOBHSD17B1BRD4MEN1ALDH1A1
SCHEMBL8272631 0.76 MAOB (0.69) MAOBBRD4HRH3MEN1ALDH1A1
SCHEMBL8283186 0.74 CASP1 (0.50) MAOBHSD17B1CASP1CASP7HSD17B10
SCHEMBL27974960 0.73 MAOB (0.66) MAOBBRD4HRH3MEN1ALDH1A1
SCHEMBL4179934 0.73 SRD5A1 (0.55) HSD17B1BRD4MEN1ALDH1A1KMT2A
SCHEMBL15927439 0.73 CNR1 (0.42) CASP1ESR1LMNACYP1A2TSHR
SCHEMBL33097 0.73 PPARD (0.35) ESR1LMNACYP1A2TSHRCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012026403-A1 CONDENSED RING COMPOUND 日本曹達株式会社 (JP) 2012-03-01 WO disclosed