Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | PPM1B | O75688 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.37 |
| ▸ | PPP5C | P53041 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27482014 | 0.89 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNAPOLBHPGDALDH1A1 | |
| SCHEMBL26261362 | 0.83 | TSHR (0.50) | SMN1; SMN2POLBALDH1A1ATMTSHR | |
| SCHEMBL3652718 | 0.82 | LMNA (0.56) | SMN1; SMN2LMNAPOLBHPGDALDH1A1 | |
| SCHEMBL20912047 | 0.82 | POLB (0.56) | SMN1; SMN2LMNAPOLBHPGDALDH1A1 | |
| SCHEMBL18498621 | 0.82 | LMNA (0.56) | SMN1; SMN2LMNAPOLBHPGDALDH1A1 | |
| SCHEMBL1633241 | 0.82 | LMNA (0.56) | SMN1; SMN2LMNAPOLBHPGDALDH1A1 | |
| SCHEMBL19308675 | 0.81 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNAPOLBHPGDALDH1A1 | |
| SCHEMBL31629521 | 0.81 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNAPOLBHPGDALDH1A1 | |
| SCHEMBL3333110 | 0.81 | LMNA (0.54) | SMN1; SMN2LMNAPOLBHPGDALDH1A1 | |
| SCHEMBL6627450 | 0.81 | LMNA (0.54) | SMN1; SMN2LMNAPOLBHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8309542-B2 | Substituted pyrrolidine amides, the production thereof, and the use thereof as medications | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-11-13 | — | — | US | disclosed |
| US-20100099664-A1 | SUBSTITUTED PYRROLIDINE AMIDES, THE PRODUCTION THEREOF, AND THE USE THEREOF AS MEDICATIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-04-22 | — | — | US | disclosed |
| CN-1232399-A | Cysteine protease inhibitors | SMITHKLINE BEECHAM CORP (US) | 1999-10-20 | — | — | CN | disclosed |
| WO-1993003026-A1 | NOVEL QUINOLONE CARBOXYLIC ACID DERIVATIVES | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 1993-02-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099664-A1 | SUBSTITUTED PYRROLIDINE AMIDES, THE PRODUCTION THEREOF, AND THE USE THEREOF AS MEDICATIONS | DDC, GLS, UROD | SMN1; SMN2 2237/4885LMNA 3711/4885POLB 1082/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.