SCHEMBL3312799

SCHEMBL3312799

CC(C)(C)OC(=O)N(CCCO)Cc1ccc2ccccc2c1

nearest known ligand 0.50

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MC3R P41968 7/20 0.50
MC4R P32245 6/20 0.50
MC5R P33032 7/20 0.43
NR1H2 P55055 1/20 0.43
HDAC3 O15379 2/20 0.42
HDAC1 Q13547 2/20 0.42
HDAC2 Q92769 2/20 0.42
SIGMAR1 Q99720 1/20 0.42
NCOR2 Q9Y618 1/20 0.42
HDAC8 Q9BY41 1/20 0.41
MC1R Q01726 1/20 0.41
CYP1A2 P05177 1/20 0.41
BCHE P06276 2/20 0.41
SSTR4 P31391 1/20 0.40
F2 P00734 1/20 0.40
F10 P00742 1/20 0.40
F7 P08709 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30941017 1.00 MC3R (0.50) MC3RMC4RMC5RNR1H2HDAC3
SCHEMBL25048605 0.89 SIGMAR1 (0.47) MC3RMC4RMC5RNR1H2HDAC1
SCHEMBL13783897 0.88 CYP1A2 (0.54) MC3RMC4RMC5RHDAC3HDAC1
SCHEMBL25048619 0.87 MC3R (0.47) MC3RMC4RMC5RHDAC3HDAC1
SCHEMBL13783902 0.85 HDAC1 (0.58) MC3RMC4RHDAC3HDAC1HDAC2
SCHEMBL1848202 0.84 HDAC1 (0.52) HDAC3HDAC1HDAC2NCOR2SSTR4
SCHEMBL25047687 0.84 MC4R (0.44) MC3RMC4RMC5RHDAC3HDAC1
SCHEMBL13783994 0.83 HDAC1 (0.65) HDAC3HDAC1HDAC2NCOR2HDAC8
SCHEMBL25047654 0.83 HDAC1 (0.47) HDAC3HDAC1HDAC2NCOR2
SCHEMBL26654244 0.82 MC4R (0.49) MC3RMC4RMC5RHDAC3HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023017152-A1 SPECIFIC SMALL MOLECULE INHIBITORS THAT BLOCK KMT9 METHYLTRANSFERASE ACTIVITY AND FUNCTION ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG (DE) 2023-02-16 WO disclosed
US-20100105915-A1 CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS ANORMED INC. (CA) 2010-04-29 US disclosed
US-7629337-B2 Chemokine receptor binding heterocyclic compounds GENZYME CORPORATION (US) 2009-12-08 US disclosed
US-7183273-B2 Chemokine receptor binding heterocyclic compounds ANORMED, INC. (CA) 2007-02-27 US disclosed
US-20060264434-A1 Chemokine receptor binding heterocyclic compounds ANORMED INC. (CA) 2006-11-23 US disclosed
EP-1163238-B1 CHEMOKINE RECPETOR BINDING HETEROCYCLIC COMPOUNDS ANORMED INC (CA) 2006-05-31 EP disclosed
US-20040235823-A1 Chemokine receptor binding heterocyclic compounds GENZYME CORPORATION 2004-11-25 US disclosed
US-6750348-B1 PROTECTIVE EFFECTS AGAINST INFECTION BY HIV THROUGH BINDING TO CHEMOKINE RECEPTORS, INCLUDING CXCR4 AND CCR5;N-(2-PYRIDINYLMETHYL)-N'-(2-(PHENYLUREIDO)ETHYL)-N'-(5,6,7,8-TETRAHYDRO-8-QUINOLINYL)-1,4-BENZENEDIMETHANAMINE ANORMED, INC. (CA) 2004-06-15 US disclosed
EP-1163238-A1 CHEMOKINE RECPETOR BINDING HETEROCYCLIC COMPOUNDS ANORMED INC. (CA) 2001-12-19 EP disclosed
WO-2000056729-A1 CHEMOKINE RECPETOR BINDING HETEROCYCLIC COMPOUNDS ANORMED INC. (CA) 2000-09-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060264434-A1 Chemokine receptor binding heterocyclic compounds CCR5, CXCR4, CXCR1 MC3R 428/4885MC4R 1099/4885MC5R 897/4885
US-20100105915-A1 CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS CXCR4, CCR5, CXCR3 MC3R 500/4885MC4R 945/4885MC5R 1405/4885
US-20040235823-A1 Chemokine receptor binding heterocyclic compounds CCR5, CXCR4, CXCR1 MC3R 498/4885MC4R 1506/4885MC5R 901/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.