Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.53 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.53 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.53 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.53 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.53 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
| ▸ | MMP13 | P45452 | 2/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MMP2 | P08253 | 2/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3318309 | 0.91 | PSEN1 (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3318177 | 0.81 | PSEN1 (0.80) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5728602 | 0.74 | ALDH1A1 (0.41) | EGFRERBB2ALDH1A1KDM4EIDO1 | |
| SCHEMBL3318073 | 0.72 | NPBWR1 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3319395 | 0.72 | NPBWR1 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3319906 | 0.71 | PSEN1 (0.65) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27884292 | 0.69 | NPBWR1 (0.47) | ALDH1A1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL27678475 | 0.68 | NPBWR1 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3320616 | 0.67 | NPBWR1 (0.45) | ALDH1A1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL3318198 | 0.67 | PSEN1 (0.59) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144812-A1 | Heterocyclic Sulfonamide Inhibitors of Beta Amyloid Production Containing an Azole | WYETH LLP (US) | 2010-06-10 | — | — | US | claimed |
| EP-1709003-B1 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION CONTAINING AN AZOLE | WYETH CORP (US) | 2009-09-23 | — | — | EP | claimed |
| US-20080249150-A1 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION CONTAINING AN AZOLE | WYETH (US) | 2008-10-09 | — | — | US | claimed |
| US-7399778-B2 | Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole | WYETH (US) | 2008-07-15 | — | — | US | claimed |
| JP-2007517905-A | — | — | 2007-07-05 | — | — | JP | claimed |
| EP-1709003-A1 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION CONTAINING AN AZOLE | Wyeth (US) | 2006-10-11 | — | — | EP | claimed |
| WO-2005073198-A1 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION CONTAINING AN AZOLE | WYETH (US) | 2005-08-11 | — | — | WO | claimed |
| US-20050171180-A1 | Heterocyclic sulfonamide inhibtors of beta amyloid production containing an azole | WYETH (US) | 2005-08-04 | — | — | US | claimed |
| US-20100144812-A1 | Heterocyclic Sulfonamide Inhibitors of Beta Amyloid Production Containing an Azole | WYETH LLP (US) | 2010-06-10 | — | — | US | disclosed |
| US-7674813-B2 | Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole | WYETH (US) | 2010-03-09 | — | — | US | disclosed |
| EP-1709003-B1 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION CONTAINING AN AZOLE | WYETH CORP (US) | 2009-09-23 | — | — | EP | disclosed |
| US-20080249150-A1 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION CONTAINING AN AZOLE | WYETH (US) | 2008-10-09 | — | — | US | disclosed |
| US-7399778-B2 | Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole | WYETH (US) | 2008-07-15 | — | — | US | disclosed |
| EP-1709003-A1 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION CONTAINING AN AZOLE | Wyeth (US) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005073198-A1 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION CONTAINING AN AZOLE | WYETH (US) | 2005-08-11 | — | — | WO | disclosed |
| US-20050171180-A1 | Heterocyclic sulfonamide inhibtors of beta amyloid production containing an azole | WYETH (US) | 2005-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144812-A1 | Heterocyclic Sulfonamide Inhibitors of Beta Amyloid Production Containing an Azole | APP, IAPP, PARK7 | PSEN1 12/4885PSEN2 21/4885APH1B 167/4885 |
| US-20080249150-A1 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION CONTAINING AN AZOLE | APP, IAPP, PARK7 | PSEN1 12/4885PSEN2 21/4885APH1B 167/4885 |
| US-20050171180-A1 | Heterocyclic sulfonamide inhibtors of beta amyloid production containing an azole | IAPP, APP, CBR3 | PSEN1 33/4885PSEN2 47/4885APH1B 237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.