Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3316459 | 0.74 | PSEN1 (0.53) | ALDH1A1SMN1; SMN2EGFRERBB2KDM4E | |
| SCHEMBL3314294 | 0.71 | NPBWR1 (0.45) | ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL29187835 | 0.70 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2GAALMNAMEN1 | |
| SCHEMBL27884291 | 0.69 | NPBWR1 (0.47) | ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL5732324 | 0.68 | NPBWR1 (0.46) | ALDH1A1SMN1; SMN2GAAKDM4ELMNA | |
| SCHEMBL29259796 | 0.68 | ALDH1A1 (0.86) | ALDH1A1SMN1; SMN2EGFRERBB2MEN1 | |
| SCHEMBL3914871 | 0.68 | ALDH1A1 (0.76) | ALDH1A1SMN1; SMN2EGFRERBB2GAA | |
| SCHEMBL3318304 | 0.67 | NPBWR1 (0.50) | ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL16578700 | 0.66 | MEN1 (0.44) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL2052679 | 0.66 | NPBWR1 (0.49) | ALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1709003-A1 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION CONTAINING AN AZOLE | Wyeth (US) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005073198-A1 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION CONTAINING AN AZOLE | WYETH (US) | 2005-08-11 | — | — | WO | disclosed |