Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | FDPS | P14324 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3316584 | 0.84 | CYP1A2 (0.61) | LMNATDP1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL3318156 | 0.83 | LMNA (0.52) | LMNATDP1CYP1A2CYP2D6CYP2C19 | |
| Hydrochloric Acid SCHEMBL28192676 | 0.81 | TDP1 (0.61) | LMNATDP1CYP1A2CYP2D6CYP2C19 | |
| Iodide SCHEMBL29037976 | 0.81 | TDP1 (0.61) | LMNATDP1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL9341301 | 0.79 | TDP1 (0.58) | LMNATDP1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL9628706 | 0.78 | LMNA (0.56) | LMNATDP1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL27678476 | 0.78 | LMNA (0.47) | LMNATDP1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL29157567 | 0.76 | LMNA (0.54) | LMNATDP1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL11291674 | 0.75 | TDP1 (0.55) | LMNATDP1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL11295490 | 0.75 | TDP1 (0.62) | LMNATDP1CYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144812-A1 | Heterocyclic Sulfonamide Inhibitors of Beta Amyloid Production Containing an Azole | WYETH LLP (US) | 2010-06-10 | — | — | US | disclosed |
| US-7674813-B2 | Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole | WYETH (US) | 2010-03-09 | — | — | US | disclosed |
| EP-1709003-B1 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION CONTAINING AN AZOLE | WYETH CORP (US) | 2009-09-23 | — | — | EP | disclosed |
| US-20080249150-A1 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION CONTAINING AN AZOLE | WYETH (US) | 2008-10-09 | — | — | US | disclosed |
| US-7399778-B2 | Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole | WYETH (US) | 2008-07-15 | — | — | US | disclosed |
| EP-1709003-A1 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION CONTAINING AN AZOLE | Wyeth (US) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005073198-A1 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION CONTAINING AN AZOLE | WYETH (US) | 2005-08-11 | — | — | WO | disclosed |
| US-20050171180-A1 | Heterocyclic sulfonamide inhibtors of beta amyloid production containing an azole | WYETH (US) | 2005-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144812-A1 | Heterocyclic Sulfonamide Inhibitors of Beta Amyloid Production Containing an Azole | APP, IAPP, PARK7 | LMNA 2937/4885TDP1 3337/4885CYP1A2 1458/4885 |
| US-20080249150-A1 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION CONTAINING AN AZOLE | APP, IAPP, PARK7 | LMNA 2937/4885TDP1 3337/4885CYP1A2 1458/4885 |
| US-20050171180-A1 | Heterocyclic sulfonamide inhibtors of beta amyloid production containing an azole | IAPP, APP, CBR3 | LMNA 2624/4885TDP1 3667/4885CYP1A2 940/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.