Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 8/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.44 |
| ▸ | EHMT1 | Q9H9B1 | 2/20 | 0.44 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.44 |
| ▸ | SLC28A1 | O00337 | 2/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.43 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.43 |
| ▸ | GAPDH | P04406 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | STAT6 | P42226 | 1/20 | 0.43 |
| ▸ | PI4KA | P42356 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.43 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.43 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28160452 | 0.84 | ADORA3 (0.45) | ADORA2AADORA3ADORA2BSLC28A1DPP4 | |
| SCHEMBL998090 | 0.83 | PI4KA (0.48) | ADORA2AADORA3ADORA2BSLC28A1DPP4 | |
| SCHEMBL2297051 | 0.83 | ADORA2A (0.47) | ADORA2AADORA3ADORA2BEHMT1EHMT2 | |
| SCHEMBL4884759 | 0.82 | EHMT1 (0.48) | ADORA2AADORA3ADORA2BEHMT1SLC28A1 | |
| SCHEMBL160357 | 0.81 | ADORA3 (0.53) | ADORA2AADORA3ADORA2BSLC28A1DPP4 | |
| SCHEMBL9495963 | 0.81 | PI4KA (0.46) | ADORA2AADORA3ADORA2BSLC28A1DPP4 | |
| SCHEMBL13268987 | 0.81 | ADORA3 (0.51) | ADORA2AADORA3ADORA2BEHMT1EHMT2 | |
| SCHEMBL3317164 | 0.79 | ADORA2A (0.47) | ADORA2AADORA3ADORA2BEHMT1EHMT2 | |
| SCHEMBL6935380 | 0.79 | PI4KA (0.48) | ADORA2AADORA3ADORA2BSLC28A1DPP4 | |
| SCHEMBL120561 | 0.79 | ADORA3 (0.50) | ADORA2AADORA3ADORA2BEHMT1EHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021350-B1 | PHOSPHORYLATED A2A RECEPTOR AGONISTS | Rheinische Friedrich-Wilhelms-Universität Bonn (DE) | 2016-12-21 | — | — | EP | disclosed |
| US-9505796-B2 | Phosphorylated A2A receptor agonists | CROZET MEDICAL GMBH (DE) | 2016-11-29 | — | — | US | disclosed |
| US-20140288019-A1 | Phosphorylated A2A Receptor Agonists | RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN (DE) | 2014-09-25 | — | — | US | disclosed |
| US-20100048501-A1 | Phosphorylated A2A Receptor Agonists | HEINRICH-HEINE-UNIVERSITAT DUSSELDORF (DE) | 2010-02-25 | — | — | US | disclosed |
| EP-2021350-A1 | PHOSPHORYLATED A2A RECEPTOR AGONISTS | Schrader, Jürgen (DE) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007107598-A1 | PHOSPHORYLATED A2A RECEPTOR AGONISTS | HEINRICH-HEINE-UNIVERSITÄT DÜSSELDORF (DE) | 2007-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048501-A1 | Phosphorylated A2A Receptor Agonists | ADORA2A, ADORA2B, ADORA3 | ADORA2A 1/4885ADORA3 3/4885ADORA2B 2/4885 |
| US-20140288019-A1 | Phosphorylated A2A Receptor Agonists | ADORA2A, ADORA2B, ADORA3 | ADORA2A 1/4885ADORA3 3/4885ADORA2B 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.