Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.68 |
| ▸ | PARP10 | Q53GL7 | 13/20 | 0.82 |
| ▸ | PARP15 | Q460N3 | 4/20 | 0.68 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.68 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.68 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.68 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.62 |
| ▸ | TNKS | O95271 | 1/20 | 0.62 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.62 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.59 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalamide SCHEMBL4205368 | 0.91 | PARP10 (1.00) | PARP10PARP15PARP14ALDH1A1KMT2A | |
| SCHEMBL606429 | 0.91 | PARP10 (1.00) | PARP10PARP15PARP14ALDH1A1KMT2A | |
| Diphenylether SCHEMBL3939335 | 0.89 | PARP10 (0.96) | PARP10PARP15PARP14ALDH1A1KMT2A | |
| Fumaric Acid SCHEMBL3023454 | 0.86 | PARP10 (0.63) | PARP10PARP15PARP14ALDH1A1KMT2A | |
| Acetic Acid SCHEMBL4630327 | 0.85 | PARP10 (0.89) | PARP10PARP15PARP14ALDH1A1KMT2A | |
| Diphenylether SCHEMBL3013964 | 0.85 | PARP10 (0.88) | PARP10PARP15PARP14ALDH1A1KMT2A | |
| Diphenylether SCHEMBL10778931 | 0.84 | ALDH1A1 (0.67) | PARP10ALDH1A1KMT2ATNKSTNKS2 | |
| Diphenylether SCHEMBL10778927 | 0.84 | ALDH1A1 (0.67) | PARP10ALDH1A1KMT2ATNKSTNKS2 | |
| SCHEMBL11018372 | 0.84 | ALDH1A1 (0.66) | PARP10ALDH1A1KMT2ASRD5A2SMN1; SMN2 | |
| SCHEMBL11018369 | 0.84 | ALDH1A1 (0.66) | PARP10ALDH1A1KMT2ASRD5A2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100105651-A1 | ANTAGONISTS OF SNS SODIUM CHANNELS | VERNALIS (R&D) LIMITED (GB) | 2010-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105651-A1 | ANTAGONISTS OF SNS SODIUM CHANNELS | CNR1, OPRL1, CHRNA10 | KMT2A 3099/4885PARP10 3132/4885PARP15 3852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.