Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.71 |
| ▸ | CA2 | P00918 | 1/20 | 0.71 |
| ▸ | CA9 | Q16790 | 1/20 | 0.71 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | LDHA | P00338 | 2/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.33 |
| ▸ | LDHB | P07195 | 1/20 | 0.33 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.33 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.33 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL22187750 | 1.00 | — | — | |
| Bicarbonate SCHEMBL6049034 | 1.00 | — | — | |
| Bicarbonate SCHEMBL28583072 | 1.00 | CA1 (0.71) | CA1CA2CA9FFAR3ACHE | |
| Bicarbonate SCHEMBL28853717 | 1.00 | — | — | |
| Bicarbonate SCHEMBL2639598 | 0.94 | CA1 (0.62) | CA1CA2CA9FFAR3ACHE | |
| Bicarbonate SCHEMBL4306718 | 0.94 | — | — | |
| Bicarbonate SCHEMBL2639602 | 0.94 | — | — | |
| Bicarbonate SCHEMBL5572362 | 0.94 | — | — | |
| Bicarbonate SCHEMBL5251123 | 0.94 | — | — | |
| Bicarbonate SCHEMBL28213934 | 0.94 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10435351-B2 | Enamide process | SUNOVION PHARMACEUTICALS INC. (US) | 2019-10-08 | — | — | US | disclosed |
| WO-2018144385-A1 | ENAMIDE PROCESS | SUNOVION PHARMACEUTICALS INC. (US) | 2018-08-09 | — | — | WO | disclosed |
| US-20180215702-A1 | ENAMIDE PROCESS | SUNOVION PHARMACEUTICALS INC. | 2018-08-02 | — | — | US | disclosed |
| US-10011559-B2 | Preparation of chiral amides and amines | SUNOVION PHARMACEUTICALS INC. (US) | 2018-07-03 | — | — | US | disclosed |
| US-20180016224-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | SUNOVION PHARMACEUTICALS INC. | 2018-01-18 | — | — | US | disclosed |
| EP-2816024-B1 | Chiral amines | SUNOVION PHARMACEUTICALS INC (US) | 2017-08-02 | — | — | EP | disclosed |
| US-20160016891-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | SUNOVION PHARMACEUTICALS INC. | 2016-01-21 | — | — | US | disclosed |
| EP-2013835-B1 | PREPARATION OF CHIRAL AMIDES AND AMINES | SUNOVION PHARMACEUTICALS INC (US) | 2015-11-04 | — | — | EP | disclosed |
| EP-2816024-A1 | Chiral amines | Sunovion Pharmaceuticals Inc. (US) | 2014-12-24 | — | — | EP | disclosed |
| US-20140057990-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | SUNOVION PHARMACEUTICALS INC. (US) | 2014-02-27 | — | — | US | disclosed |
| US-8524950-B2 | Preparation of chiral amides and amines | SUNOVION PHARMACEUTICALS INC. (US) | 2013-09-03 | — | — | US | disclosed |
| US-20120095106-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | SUNOVION PHARMACEUTICALS INC. (US) | 2012-04-19 | — | — | US | disclosed |
| US-8097760-B2 | Preparation of chiral amides and amines | Sunovion Pharmacuticals Inc. (US) | 2012-01-17 | — | — | US | disclosed |
| US-20090149549-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | SUNOVION PHARMACEUTICALS INC. | 2009-06-11 | — | — | US | disclosed |
| EP-2013835-A2 | PREPARATION OF CHIRAL AMIDES AND AMINES | Sepracor Inc. (US) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007115185-A2 | PREPARATION OF CHIRAL AMIDES AND AMINES | SEPRACOR INC. (US) | 2007-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10011559-B2 | Preparation of chiral amides and amines | PNMT, ALKBH5, ALKBH2 | CA1 425/4885CA2 1010/4885CA9 1175/4885 |
| US-20180016224-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | PNMT, ALKBH2, ALKBH5 | CA1 407/4885CA2 951/4885CA9 953/4885 |
| US-20160016891-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | PNMT, ALKBH5, ALKBH2 | CA1 425/4885CA2 1010/4885CA9 1175/4885 |
| US-20090149549-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | PNMT, ALKBH5, ALKBH2 | CA1 425/4885CA2 1010/4885CA9 1175/4885 |
| US-20120095106-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | PNMT, ALKBH5, ALKBH2 | CA1 425/4885CA2 1010/4885CA9 1175/4885 |
| US-20180215702-A1 | ENAMIDE PROCESS | ENO1, ENY2, ALKBH2 | CA1 1028/4885CA2 1138/4885CA9 727/4885 |
| US-10435351-B2 | Enamide process | ENO1, ENY2, ALKBH2 | CA1 1028/4885CA2 1138/4885CA9 727/4885 |
| US-20140057990-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | PNMT, ALKBH5, ALKBH2 | CA1 425/4885CA2 1010/4885CA9 1175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.