Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLOD2 | O00469 | 1/20 | 0.59 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.59 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 3/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1286697 | 0.85 | PLOD2 (0.60) | PLOD2PLOD3PLOD1ADRA2CHTR2C | |
| SCHEMBL3319386 | 0.85 | ALDH1A1 (0.73) | PLOD2PLOD3PLOD1ADRA2CHTR2C | |
| SCHEMBL30760618 | 0.85 | ADRA2C (0.62) | PLOD2PLOD3PLOD1ADRA2CHTR2C | |
| SCHEMBL1397689 | 0.85 | ADRA2C (0.62) | PLOD2PLOD3PLOD1ADRA2CHTR2C | |
| SCHEMBL29631156 | 0.85 | ALDH1A1 (0.73) | PLOD2PLOD3PLOD1ADRA2CHTR2C | |
| SCHEMBL27746847 | 0.85 | ALDH1A1 (0.72) | KDM4EMEN1ALDH1A1GAAHPGD | |
| Hydrochloric Acid SCHEMBL16209753 | 0.84 | ADRA2C (0.60) | PLOD2PLOD3PLOD1ADRA2CHTR2C | |
| Hydrochloric Acid SCHEMBL30760605 | 0.84 | ADRA2C (0.60) | PLOD2PLOD3PLOD1ADRA2CHTR2C | |
| SCHEMBL27767932 | 0.83 | ALDH1A1 (0.70) | KDM4EMEN1ALDH1A1GAAHPGD | |
| SCHEMBL29053020 | 0.83 | PLOD2 (0.58) | PLOD2PLOD3PLOD1ADRA2CHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100105652-A1 | PURINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED | 2010-04-29 | — | — | US | disclosed |
| EP-2118106-A1 | PURINES AS CYSTEINE PROTEASE INHIBITORS | Glaxo Group Limited (GB) | 2009-11-18 | — | — | EP | disclosed |
| EP-2028182-A1 | Cysteine protease inhibitors | GLAXO GROUP LIMITED (GB) | 2009-02-25 | — | — | EP | disclosed |
| WO-2008107368-A1 | PURINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2008-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105652-A1 | PURINES AS CYSTEINE PROTEASE INHIBITORS | CPN1, SERPINB1, PNP | PLOD2 3992/4885PLOD3 3381/4885PLOD1 3439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.