Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 5/20 | 0.55 |
| ▸ | FABP3 | P05413 | 4/20 | 0.55 |
| ▸ | FABP5 | Q01469 | 4/20 | 0.49 |
| ▸ | SPR | P35270 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.44 |
| ▸ | FASN | P49327 | 2/20 | 0.44 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PRNP | P04156 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3322283 | 0.81 | FABP4 (0.69) | FABP4FABP3FABP5KDM4EPLA2G2A | |
| SCHEMBL13363406 | 0.77 | PARP10 (0.40) | SPRFASNPARP14PARP10CCR1 | |
| SCHEMBL21083000 | 0.73 | FABP4 (1.00) | FABP4FABP3FABP5KDM4EPLA2G2A | |
| SCHEMBL2820951 | 0.72 | FABP4 (0.82) | FABP4FABP3FABP5KDM4EPLA2G2A | |
| SCHEMBL3319814 | 0.69 | FABP4 (0.65) | FABP4FABP3FABP5KDM4EPLA2G2A | |
| SCHEMBL6969338 | 0.68 | MGLL (0.48) | FABP4FABP5AVPR1ACNR1CNR2 | |
| SCHEMBL3322903 | 0.67 | FABP4 (0.73) | FABP4FABP3FABP5KDM4EPLA2G2A | |
| SCHEMBL3900559 | 0.67 | AVPR1A (0.61) | SPRAVPR1APARP14PARP10CNR1 | |
| SCHEMBL14916776 | 0.67 | FABP4 (1.00) | FABP4FABP3FABP5KDM4EPLA2G2A | |
| SCHEMBL3321673 | 0.67 | FABP4 (0.61) | FABP4FABP3FABP5KDM4EPLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865739-B2 | Substituted heterocyclic compounds as ion channel modulators | GILEAD SCIENCES, INC. (US) | 2014-10-21 | — | — | US | claimed |
| US-20140107155-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | GILEAD SCIENCES, INC. (US) | 2014-04-17 | — | — | US | claimed |
| US-8664399-B2 | Substituted heterocyclic compounds as ion channel modulators | GILEAD SCIENCES, INC. (US) | 2014-03-04 | — | — | US | claimed |
| US-20130102632-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | GILEAD SCIENCES, INC. (US) | 2013-04-25 | — | — | US | claimed |
| US-20100125091-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | GILEAD PALO ALTO, INC. (US) | 2010-05-20 | — | — | US | claimed |
| WO-2010056865-A1 | QUINOLINE DERIVATIVES AS ION CHANNEL MODULATORS | GILEAD PALO ALTO, INC. (US) | 2010-05-20 | — | — | WO | claimed |
| US-8865739-B2 | Substituted heterocyclic compounds as ion channel modulators | GILEAD SCIENCES, INC. (US) | 2014-10-21 | — | — | US | disclosed |
| US-8865739-B2 | Substituted heterocyclic compounds as ion channel modulators | GILEAD SCIENCES, INC. (US) | 2014-10-21 | — | — | US | disclosed |
| US-8865739-B2 | Substituted heterocyclic compounds as ion channel modulators | GILEAD SCIENCES, INC. (US) | 2014-10-21 | — | — | US | disclosed |
| US-20140107155-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | GILEAD SCIENCES, INC. (US) | 2014-04-17 | — | — | US | disclosed |
| US-20140107155-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | GILEAD SCIENCES, INC. (US) | 2014-04-17 | — | — | US | disclosed |
| US-20140107155-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | GILEAD SCIENCES, INC. (US) | 2014-04-17 | — | — | US | disclosed |
| US-8664399-B2 | Substituted heterocyclic compounds as ion channel modulators | GILEAD SCIENCES, INC. (US) | 2014-03-04 | — | — | US | disclosed |
| US-20130102632-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | GILEAD SCIENCES, INC. (US) | 2013-04-25 | — | — | US | disclosed |
| US-20130102632-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | GILEAD SCIENCES, INC. (US) | 2013-04-25 | — | — | US | disclosed |
| US-20100125091-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | GILEAD PALO ALTO, INC. (US) | 2010-05-20 | — | — | US | disclosed |
| US-20100125091-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | GILEAD PALO ALTO, INC. (US) | 2010-05-20 | — | — | US | disclosed |
| US-20100125091-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | GILEAD PALO ALTO, INC. (US) | 2010-05-20 | — | — | US | disclosed |
| WO-2010056865-A1 | QUINOLINE DERIVATIVES AS ION CHANNEL MODULATORS | GILEAD PALO ALTO, INC. (US) | 2010-05-20 | — | — | WO | disclosed |
| WO-2010056865-A1 | QUINOLINE DERIVATIVES AS ION CHANNEL MODULATORS | GILEAD PALO ALTO, INC. (US) | 2010-05-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140107155-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | KCNH2, KCNJ2, CACNA1E | FABP4 3868/4885FABP3 1216/4885FABP5 3822/4885 |
| US-20100125091-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | KCNH2, KCNJ2, CACNA1E | FABP4 3868/4885FABP3 1216/4885FABP5 3822/4885 |
| US-20130102632-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | KCNH2, KCNJ2, CACNA1E | FABP4 3868/4885FABP3 1216/4885FABP5 3822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.