Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | FABP4 | P15090 | 1/20 | 0.46 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 2/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6976291 | 0.86 | LMNA (0.55) | MEN1KMT2ALMNAMAP3K12ACHE | |
| SCHEMBL6977642 | 0.84 | MAPK7 (0.57) | MEN1KMT2ALMNAACHE | |
| SCHEMBL6974879 | 0.76 | DRD2 (0.65) | MGLLMEN1KMT2ALMNAMAPT | |
| SCHEMBL6981223 | 0.75 | ACHE (0.55) | MGLLMEN1KMT2ALMNAMAP3K12 | |
| SCHEMBL6973351 | 0.74 | DRD2 (0.52) | MGLLMEN1KMT2ALMNAMAPT | |
| SCHEMBL6974797 | 0.74 | ACHE (0.48) | KMT2ALMNAFABP4FABP5ACHE | |
| SCHEMBL6968387 | 0.73 | ALDH1A1 (0.51) | MEN1KMT2A | |
| SCHEMBL6969942 | 0.71 | MAP3K12 (0.60) | LMNAMAP3K12ACHE | |
| SCHEMBL16628710 | 0.71 | HSP90AA1 (0.76) | LMNA | |
| SCHEMBL6976998 | 0.70 | KDM4E (0.53) | LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892795-B1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMA (JP) | 2003-01-08 | — | — | EP | disclosed |
| US-5948786-A | BLOCKING TUMOR NECROSIS FACTOR | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-09-07 | — | — | US | disclosed |
| EP-0892795-A1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997038992-A1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-10-23 | — | — | WO | disclosed |