Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1867735 | 0.84 | NPSR1 (0.53) | NPSR1ALDH1A1TSHRUSP2HPGD | |
| SCHEMBL13746186 | 0.84 | NPSR1 (0.72) | NPSR1ALDH1A1TSHRUSP2HPGD | |
| SCHEMBL13746187 | 0.78 | MAPT (0.62) | NPSR1ALDH1A1MAPTPOLBPKM | |
| SCHEMBL24423083 | 0.77 | KMT2A (0.63) | MAPTPOLBKMT2A | |
| SCHEMBL13621146 | 0.77 | ALDH1A1 (0.74) | ALDH1A1CYP2C9TSHRCYP2C19MAPT | |
| SCHEMBL24422954 | 0.77 | ALDH1A1 (0.58) | NPSR1ALDH1A1TSHRPOLBPKM | |
| SCHEMBL12993901 | 0.77 | ALDH1A1 (0.67) | ALDH1A1TSHRUSP2PKMKMT2A | |
| SCHEMBL8372164 | 0.77 | MEN1 (0.61) | NPSR1ALDH1A1TSHRUSP2HPGD | |
| SCHEMBL13745754 | 0.76 | ALDH1A1 (0.62) | ALDH1A1POLBEPHX2KMT2A | |
| SCHEMBL27370874 | 0.76 | NPSR1 (0.64) | NPSR1ALDH1A1TSHRUSP2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216767-A1 | QUINAZOLINES FOR PDK1 INHIBITION | AIKAWA MINA | 2010-08-26 | — | — | US | disclosed |
| US-20100121052-A1 | Novel compounds for treating proliferative diseases | JAIN RAMA | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216767-A1 | QUINAZOLINES FOR PDK1 INHIBITION | PDK1, PDK2, PDK3 | NPSR1 4272/4885ALDH1A1 2630/4885CYP2C9 4755/4885 |
| US-20100121052-A1 | Novel compounds for treating proliferative diseases | PDK1, PDK2, PDK3 | NPSR1 4212/4885ALDH1A1 2281/4885CYP2C9 4866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.