Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.60 |
| ▸ | NR3C2 | P08235 | 5/20 | 0.60 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.60 |
| ▸ | HSD11B2 | P80365 | 2/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.59 |
| ▸ | LMNA | P02545 | 5/20 | 0.59 |
| ▸ | SHBG | P04278 | 6/20 | 0.57 |
| ▸ | SERPINA6 | P08185 | 5/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.57 |
| ▸ | BLM | P54132 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.57 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.57 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.57 |
| ▸ | THPO | P40225 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3671489 | 0.88 | HIF1A (0.59) | SMN1; SMN2NR3C2HSD11B1HSD11B2HIF1A | |
| SCHEMBL9459018 | 0.88 | HIF1A (0.59) | SMN1; SMN2NR3C2HSD11B1HSD11B2HIF1A | |
| SCHEMBL11480876 | 0.88 | HIF1A (0.59) | SMN1; SMN2NR3C2HSD11B1HSD11B2HIF1A | |
| SCHEMBL30496663 | 0.88 | HIF1A (0.59) | SMN1; SMN2NR3C2HSD11B1HSD11B2HIF1A | |
| SCHEMBL6013906 | 0.88 | HIF1A (0.59) | SMN1; SMN2NR3C2HSD11B1HSD11B2HIF1A | |
| SCHEMBL23864218 | 0.86 | SMN1; SMN2 (0.67) | SMN1; SMN2NR3C2HSD11B1HSD11B2HIF1A | |
| SCHEMBL10301232 | 0.86 | SMN1; SMN2 (0.67) | SMN1; SMN2NR3C2HSD11B1HSD11B2HIF1A | |
| SCHEMBL14284911 | 0.86 | SMN1; SMN2 (0.67) | SMN1; SMN2NR3C2HSD11B1HSD11B2HIF1A | |
| SCHEMBL13753020 | 0.86 | SMN1; SMN2 (0.67) | SMN1; SMN2NR3C2HSD11B1HSD11B2HIF1A | |
| SCHEMBL20058429 | 0.86 | SMN1; SMN2 (0.67) | SMN1; SMN2NR3C2HSD11B1HSD11B2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100120736-A1 | Mineralocorticoid Receptor Antagonists | N.V. ORGANON | 2010-05-13 | — | — | US | disclosed |
| US-20100120736-A1 | Mineralocorticoid Receptor Antagonists | N.V. ORGANON | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120736-A1 | Mineralocorticoid Receptor Antagonists | NR3C2, AGTR1, AGTR2 | SMN1; SMN2 4419/4885NR3C2 1/4885HSD11B1 32/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.