Sugi Predict

Sugi Predict / Compounds / SCHEMBL332240

SCHEMBL332240

SCHEMBL332240

Cn1nccc1-c1ccc(Sc2cc(C3(C(N)=O)CCOCC3)ccc2F)cc1

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALOX5 P09917 5/20 0.76
▸ AKT1 P31749 5/20 0.37
▸ PIK3CD O00329 1/20 0.36
▸ CD274 Q9NZQ7 1/20 0.36
▸ AKT2 P31751 3/20 0.35
▸ HRH3 Q9Y5N1 1/20 0.34
▸ USP30 Q70CQ3 1/20 0.34
▸ SGK1 O00141 2/20 0.33
▸ RPS6KB1 P23443 2/20 0.33
▸ PRKCQ Q04759 2/20 0.33
▸ ROCK1 Q13464 2/20 0.33
▸ RPS6KA1 Q15418 2/20 0.33
▸ AKT3 Q9Y243 2/20 0.33
▸ ROCK2 O75116 1/20 0.33
▸ JAK1 P23458 1/20 0.33
▸ JAK3 P52333 1/20 0.33
▸ HDAC4 P56524 1/20 0.33
▸ P2RX7 Q99572 1/20 0.33
▸ CYP11B2 P19099 1/20 0.33
▸ ABL1 P00519 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL332034 0.89 ALOX5 (0.60) ALOX5AKT1PIK3CDCD274AKT2
SCHEMBL332537 0.87 ALOX5 (0.74) ALOX5AKT1PIK3CDCD274HRH3
SCHEMBL332862 0.84 ALOX5 (0.78) ALOX5AKT1PIK3CDCD274AKT2
Pf-4191834 SCHEMBL29369341 0.83 ALOX5 (0.81) ALOX5AKT1PIK3CDCD274HRH3
Pf-4191834 SCHEMBL332973 0.83 ALOX5 (0.81) ALOX5AKT1PIK3CDCD274HRH3
SCHEMBL332786 0.83 ALOX5 (0.61) ALOX5AKT1PIK3CDCD274AKT2
SCHEMBL332324 0.82 ALOX5 (0.66) ALOX5AKT1PIK3CDCD274AKT2
SCHEMBL332778 0.81 ALOX5 (0.67) ALOX5AKT1PIK3CDCD274AKT2
SCHEMBL332517 0.81 ALOX5 (0.67) ALOX5AKT1PIK3CDCD274JAK1
SCHEMBL13807145 0.78 ALOX5 (0.46) ALOX5HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2225229-A1 PYRAZOLE DERIVATIVES AS 5-LO INHIBITORS Pfizer Inc. (US) 2010-09-08 — — EP claimed
US-20090227634-A1 Pyrazole Derivatives as 5-LO-Inhibitors PFIZER INC. 2009-09-10 — — US claimed
WO-2009069044-A1 PYRAZOLE DERIVATIVES AS 5-LO INHIBITORS PFIZER INC. (US) 2009-06-04 — — WO claimed
US-8097733-B2 Pyrazole derivatives as 5-LO-inhibitors PFIZER INC. (US) 2012-01-17 — — US disclosed
US-8097733-B2 Pyrazole derivatives as 5-LO-inhibitors PFIZER INC. (US) 2012-01-17 — — US disclosed
US-8097733-B2 Pyrazole derivatives as 5-LO-inhibitors PFIZER INC. (US) 2012-01-17 — — US disclosed
EP-2225229-A1 PYRAZOLE DERIVATIVES AS 5-LO INHIBITORS Pfizer Inc. (US) 2010-09-08 — — EP disclosed
US-20090227634-A1 Pyrazole Derivatives as 5-LO-Inhibitors PFIZER INC. 2009-09-10 — — US disclosed
US-20090227634-A1 Pyrazole Derivatives as 5-LO-Inhibitors PFIZER INC. 2009-09-10 — — US disclosed
US-20090227634-A1 Pyrazole Derivatives as 5-LO-Inhibitors PFIZER INC. 2009-09-10 — — US disclosed
WO-2009069044-A1 PYRAZOLE DERIVATIVES AS 5-LO INHIBITORS PFIZER INC. (US) 2009-06-04 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090227634-A1 Pyrazole Derivatives as 5-LO-Inhibitors ALOX5, ALOX15, CYP3A5 ALOX5 1/4885AKT1 3057/4885PIK3CD 1305/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.