Sugi Predict

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SCHEMBL332778

SCHEMBL332778

Cn1nccc1-c1ccc(Sc2c(F)ccc(C3(C(N)=O)CCOCC3)c2F)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALOX5 P09917 6/20 0.67
▸ CD274 Q9NZQ7 1/20 0.36
▸ AKT1 P31749 5/20 0.33
▸ AKT2 P31751 3/20 0.33
▸ HDAC4 P56524 1/20 0.33
▸ ABL1 P00519 1/20 0.32
▸ HTR2A P28223 1/20 0.31
▸ SGK1 O00141 2/20 0.31
▸ RPS6KB1 P23443 2/20 0.31
▸ PRKCQ Q04759 2/20 0.31
▸ ROCK1 Q13464 2/20 0.31
▸ RPS6KA1 Q15418 2/20 0.31
▸ AKT3 Q9Y243 2/20 0.31
▸ ROCK2 O75116 1/20 0.31
▸ JAK1 P23458 1/20 0.31
▸ JAK3 P52333 1/20 0.31
▸ P2RX7 Q99572 1/20 0.31
▸ SLC13A5 Q86YT5 1/20 0.31
▸ USP30 Q70CQ3 1/20 0.30
▸ PIK3CD O00329 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL332455 0.89 ALOX5 (0.55) ALOX5CD274AKT1AKT2SGK1
SCHEMBL332517 0.85 ALOX5 (0.67) ALOX5CD274AKT1HDAC4ABL1
SCHEMBL332324 0.82 ALOX5 (0.66) ALOX5CD274AKT1AKT2HDAC4
SCHEMBL332240 0.81 ALOX5 (0.76) ALOX5CD274AKT1AKT2HDAC4
SCHEMBL333246 0.81 ALOX5 (0.46) ALOX5CD274USP30
SCHEMBL332862 0.78 ALOX5 (0.78) ALOX5CD274AKT1AKT2ABL1
Pf-4191834 SCHEMBL332973 0.76 ALOX5 (0.81) ALOX5CD274AKT1ABL1JAK1
Pf-4191834 SCHEMBL29369341 0.76 ALOX5 (0.81) ALOX5CD274AKT1ABL1JAK1
SCHEMBL332034 0.74 ALOX5 (0.60) ALOX5CD274AKT1AKT2ABL1
SCHEMBL332552 0.74 ALOX5 (0.55) ALOX5CD274AKT1HDAC4ABL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2225229-A1 PYRAZOLE DERIVATIVES AS 5-LO INHIBITORS Pfizer Inc. (US) 2010-09-08 — — EP claimed
US-20090227634-A1 Pyrazole Derivatives as 5-LO-Inhibitors PFIZER INC. 2009-09-10 — — US claimed
WO-2009069044-A1 PYRAZOLE DERIVATIVES AS 5-LO INHIBITORS PFIZER INC. (US) 2009-06-04 — — WO claimed
US-8097733-B2 Pyrazole derivatives as 5-LO-inhibitors PFIZER INC. (US) 2012-01-17 — — US disclosed
US-8097733-B2 Pyrazole derivatives as 5-LO-inhibitors PFIZER INC. (US) 2012-01-17 — — US disclosed
US-8097733-B2 Pyrazole derivatives as 5-LO-inhibitors PFIZER INC. (US) 2012-01-17 — — US disclosed
EP-2225229-A1 PYRAZOLE DERIVATIVES AS 5-LO INHIBITORS Pfizer Inc. (US) 2010-09-08 — — EP disclosed
US-20090227634-A1 Pyrazole Derivatives as 5-LO-Inhibitors PFIZER INC. 2009-09-10 — — US disclosed
US-20090227634-A1 Pyrazole Derivatives as 5-LO-Inhibitors PFIZER INC. 2009-09-10 — — US disclosed
US-20090227634-A1 Pyrazole Derivatives as 5-LO-Inhibitors PFIZER INC. 2009-09-10 — — US disclosed
WO-2009069044-A1 PYRAZOLE DERIVATIVES AS 5-LO INHIBITORS PFIZER INC. (US) 2009-06-04 — — WO disclosed
WO-2009069044-A1 PYRAZOLE DERIVATIVES AS 5-LO INHIBITORS PFIZER INC. (US) 2009-06-04 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090227634-A1 Pyrazole Derivatives as 5-LO-Inhibitors ALOX5, ALOX15, CYP3A5 ALOX5 1/4885CD274 2601/4885AKT1 3057/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.