Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.66 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 4/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | AKT2 | P31751 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL332471 | 0.89 | ALOX5 (0.54) | ALOX5CD274AKT1ABL1AKT2 | |
| SCHEMBL332517 | 0.88 | ALOX5 (0.67) | ALOX5CD274AKT1ABL1JAK1 | |
| SCHEMBL332862 | 0.83 | ALOX5 (0.78) | ALOX5CD274AKT1ABL1AKT2 | |
| SCHEMBL332240 | 0.82 | ALOX5 (0.76) | ALOX5CD274AKT1ABL1AKT2 | |
| SCHEMBL332778 | 0.82 | ALOX5 (0.67) | ALOX5CD274AKT1ABL1AKT2 | |
| SCHEMBL332552 | 0.77 | ALOX5 (0.55) | ALOX5CD274AKT1ABL1JAK1 | |
| SCHEMBL332537 | 0.77 | ALOX5 (0.74) | ALOX5CD274AKT1PIK3CD | |
| SCHEMBL331664 | 0.77 | ALOX5 (0.55) | ALOX5CD274AKT1ABL1P2RX7 | |
| Pf-4191834 SCHEMBL29369341 | 0.77 | ALOX5 (0.81) | ALOX5CD274AKT1ABL1JAK1 | |
| Pf-4191834 SCHEMBL332973 | 0.77 | ALOX5 (0.81) | ALOX5CD274AKT1ABL1JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8097733-B2 | Pyrazole derivatives as 5-LO-inhibitors | PFIZER INC. (US) | 2012-01-17 | — | — | US | disclosed |
| US-20090227634-A1 | Pyrazole Derivatives as 5-LO-Inhibitors | PFIZER INC. | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227634-A1 | Pyrazole Derivatives as 5-LO-Inhibitors | ALOX5, ALOX15, CYP3A5 | ALOX5 1/4885CD274 2601/4885AKT1 3057/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.