Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | ADAMTS7 | Q9UKP4 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL332929 | 0.81 | HTT (0.52) | HTTSCN10AP2RX7 | |
| SCHEMBL28462767 | 0.77 | KMT2A (0.55) | ATMKMT2AHCRTR1HCRTR2P2RX7 | |
| SCHEMBL332638 | 0.73 | HTT (0.71) | ATMKMT2AHTTSCN10AL3MBTL1 | |
| SCHEMBL27278396 | 0.72 | HTT (0.67) | KMT2AHTTL3MBTL1 | |
| SCHEMBL2074860 | 0.71 | KMT2A (0.49) | SMOATMKMT2AHCRTR1HCRTR2 | |
| SCHEMBL30133947 | 0.71 | KMT2A (0.49) | SMOATMKMT2AHCRTR1HCRTR2 | |
| SCHEMBL334641 | 0.70 | KEAP1 (0.52) | ATMKMT2AHCRTR1HCRTR2CES2 | |
| SCHEMBL5657844 | 0.70 | PTGS1 (0.46) | ATMKMT2AHCRTR1HCRTR2P2RX7 | |
| SCHEMBL5655050 | 0.69 | GRM4 (0.50) | ATMKMT2AHTTP2RX7L3MBTL1 | |
| SCHEMBL3213469 | 0.69 | CES2 (0.48) | SMOATMKMT2AHCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8097733-B2 | Pyrazole derivatives as 5-LO-inhibitors | PFIZER INC. (US) | 2012-01-17 | — | — | US | disclosed |
| US-20090227634-A1 | Pyrazole Derivatives as 5-LO-Inhibitors | PFIZER INC. | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227634-A1 | Pyrazole Derivatives as 5-LO-Inhibitors | ALOX5, ALOX15, CYP3A5 | SMO 3657/4885ATM 4097/4885KMT2A 3974/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.