Sugi Predict

Sugi Predict / Compounds / SCHEMBL3326031

SCHEMBL3326031

SCHEMBL3326031

CCOc1ccnc(Nc2n[nH]c3c2CN(C(=O)Cl)C3(C)C)n1

nearest known ligand 0.70

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ PRKCB P05771 9/20 0.70
▸ PAK4 O96013 11/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3327583 0.82 PRKCB (1.00) PRKCB
SCHEMBL14103855 0.82 PRKCB (0.79) PRKCB
SCHEMBL16624987 0.78 PRKCB (0.76) PRKCB
SCHEMBL7014150 0.78 PRKCB (0.54) PRKCBPAK4
SCHEMBL3330296 0.78 PRKCB (1.00) PRKCB
Hydrochloric Acid SCHEMBL3323095 0.77 PRKCB (0.53) PRKCBPAK4
Ethyl Acetate SCHEMBL3327751 0.73 PRKCB (0.61) PRKCBPAK4
SCHEMBL7017047 0.71 PRKCB (0.70) PRKCBPAK4
SCHEMBL29483938 0.71 PRKCB (0.70) PRKCBPAK4
SCHEMBL22217131 0.71 PRKCB (0.71) PRKCBPAK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11780853-B2 Substituted N-pyrimidin-4-yl-3-aminopyrrolo[3,4-C]pyrazoles as protein kinase C inhibitors PFIZER INC. (US) 2023-10-10 — — US disclosed
US-11780853-B2 Substituted N-pyrimidin-4-yl-3-aminopyrrolo[3,4-C]pyrazoles as protein kinase C inhibitors PFIZER INC. (US) 2023-10-10 — — US disclosed
US-20220089613-A1 NOVEL 3-AMINO-PYRROLO[3,4-C]PYRAZOLE-5(1H, 4H,6H) CARBALDEHYDE DERIVATIVES PFIZER INC. 2022-03-24 — — US disclosed
US-11220518-B2 Substituted n-pyrimidin-4-yl-3-amino-pyrrolo[3,4-c]pyrazoles as protein kinase C inhibitors PFIZER INC. (US) 2022-01-11 — — US disclosed
US-11220518-B2 Substituted n-pyrimidin-4-yl-3-amino-pyrrolo[3,4-c]pyrazoles as protein kinase C inhibitors PFIZER INC. (US) 2022-01-11 — — US disclosed
US-10316045-B2 Substituted pyrrolo[3,4-c]pyrazoles as pkc kinase inhibitors PFIZER INC. (US) 2019-06-11 — — US disclosed
US-10316045-B2 Substituted pyrrolo[3,4-c]pyrazoles as pkc kinase inhibitors PFIZER INC. (US) 2019-06-11 — — US disclosed
US-20170217991-A1 NOVEL 3-AMINO-PYRROLO[3,4-C]PYRAZOLE-5(1H, 4H,6H) CARBALDEHYDE DERIVATIVES PFIZER INC. 2017-08-03 — — US disclosed
US-20170217991-A1 NOVEL 3-AMINO-PYRROLO[3,4-C]PYRAZOLE-5(1H, 4H,6H) CARBALDEHYDE DERIVATIVES PFIZER INC. 2017-08-03 — — US disclosed
US-20170217991-A1 NOVEL 3-AMINO-PYRROLO[3,4-C]PYRAZOLE-5(1H, 4H,6H) CARBALDEHYDE DERIVATIVES PFIZER INC. 2017-08-03 — — US disclosed
US-20120202809-A1 NOVEL N-PYRIMIDIN-4-YL-3-AMINO-PYRROLO[3,4-C]PYRAZOLE DERIVATIVES AS PKC KINASE INHIBITORS PFIZER INC. 2012-08-09 — — US disclosed
US-20120202809-A1 NOVEL N-PYRIMIDIN-4-YL-3-AMINO-PYRROLO[3,4-C]PYRAZOLE DERIVATIVES AS PKC KINASE INHIBITORS PFIZER INC. 2012-08-09 — — US disclosed
US-8183255-B2 N-pyrimidin-4-yl-3-amino-pyrrolo[3,4-c]pyrazole derivatives as PKC kinase inhibitors PFIZER, INC. (US) 2012-05-22 — — US disclosed
US-8183255-B2 N-pyrimidin-4-yl-3-amino-pyrrolo[3,4-c]pyrazole derivatives as PKC kinase inhibitors PFIZER, INC. (US) 2012-05-22 — — US disclosed
US-8183255-B2 N-pyrimidin-4-yl-3-amino-pyrrolo[3,4-c]pyrazole derivatives as PKC kinase inhibitors PFIZER, INC. (US) 2012-05-22 — — US disclosed
US-20100130501-A1 NOVEL 3-AMINO-PYRROLO[3,4-C]PYRAZOLE-5(1H, 4H, 6H) CARBALDEHYDE DERIVATIVES PFIZER INC. 2010-05-27 — — US disclosed
US-20100130501-A1 NOVEL 3-AMINO-PYRROLO[3,4-C]PYRAZOLE-5(1H, 4H, 6H) CARBALDEHYDE DERIVATIVES PFIZER INC. 2010-05-27 — — US disclosed
US-20100130501-A1 NOVEL 3-AMINO-PYRROLO[3,4-C]PYRAZOLE-5(1H, 4H, 6H) CARBALDEHYDE DERIVATIVES PFIZER INC. 2010-05-27 — — US disclosed
EP-2118112-A1 3-AMINO-PYRROLO[3,4-C] PYRAZOLE- 5 (1H, 4H, 6H) CARBALDEHYDE DERIVATIVES AS PKC INHIBITORS Pfizer Inc. (US) 2009-11-18 — — EP disclosed
WO-2008096260-A1 3-AMINO-PYRROLO[3,4-C] PYRAZOLE- 5 (1H, 4H, 6H) CARBALDEHYDE DERIVATIVES AS PKC INHIBITORS PFIZER INC. (US) 2008-08-14 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170217991-A1 NOVEL 3-AMINO-PYRROLO[3,4-C]PYRAZOLE-5(1H, 4H,6H) CARBALDEHYDE DERIVATIVES INSR, IAPP, GPR119 PRKCB 1116/4885PAK4 3757/4885
US-10316045-B2 Substituted pyrrolo[3,4-c]pyrazoles as pkc kinase inhibitors PRKCB, PRKCA, PRKCE PRKCB 1/4885PAK4 710/4885
US-11780853-B2 Substituted N-pyrimidin-4-yl-3-aminopyrrolo[3,4-C]pyrazoles as protein kinase C inhibitors PRKCB, PRKCA, PRKCQ PRKCB 1/4885PAK4 969/4885
US-11220518-B2 Substituted n-pyrimidin-4-yl-3-amino-pyrrolo[3,4-c]pyrazoles as protein kinase C inhibitors JAK3, PRKCB, PRKCA PRKCB 2/4885PAK4 475/4885
US-20100130501-A1 NOVEL 3-AMINO-PYRROLO[3,4-C]PYRAZOLE-5(1H, 4H, 6H) CARBALDEHYDE DERIVATIVES DPP3, IAPP, GPR119 PRKCB 990/4885PAK4 3900/4885
US-20220089613-A1 NOVEL 3-AMINO-PYRROLO[3,4-C]PYRAZOLE-5(1H, 4H,6H) CARBALDEHYDE DERIVATIVES INSR, IAPP, GPR119 PRKCB 1116/4885PAK4 3757/4885
US-20120202809-A1 NOVEL N-PYRIMIDIN-4-YL-3-AMINO-PYRROLO[3,4-C]PYRAZOLE DERIVATIVES AS PKC KINASE INHIBITORS PRKCB, PRKCA, PRKCE PRKCB 1/4885PAK4 623/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.