Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 9/20 | 0.50 |
| ▸ | MAOA | P21397 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.38 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | BCR | P11274 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3326842 | 0.87 | ALDH1A1 (0.60) | ALDH1A1HPGDRAB9ASMN1; SMN2MAOB | |
| SCHEMBL3328170 | 0.85 | ALDH1A1 (0.60) | ALDH1A1HPGDRAB9ASMN1; SMN2MAOB | |
| SCHEMBL3326709 | 0.81 | ALDH1A1 (0.54) | ALDH1A1HPGDRAB9ASMN1; SMN2MAOB | |
| SCHEMBL3323851 | 0.81 | MAOB (0.51) | ALDH1A1HPGDRAB9ASMN1; SMN2MAOB | |
| SCHEMBL3327514 | 0.81 | ALDH1A1 (0.51) | ALDH1A1HPGDRAB9ASMN1; SMN2MAOB | |
| SCHEMBL14037178 | 0.81 | ALDH1A1 (0.60) | ALDH1A1HPGDRAB9ASMN1; SMN2MAOB | |
| SCHEMBL3326527 | 0.81 | MAOB (0.51) | ALDH1A1HPGDRAB9ASMN1; SMN2MAOB | |
| SCHEMBL3328864 | 0.80 | ALDH1A1 (0.49) | ALDH1A1HPGDRAB9ASMN1; SMN2MAOB | |
| SCHEMBL979299 | 0.80 | MAOB (0.65) | ALDH1A1HPGDRAB9ASMN1; SMN2MAOB | |
| SCHEMBL3328030 | 0.80 | ALDH1A1 (0.50) | ALDH1A1HPGDRAB9ASMN1; SMN2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148865-B1 | PYRAZOLE INHIBITORS OF WNT SIGNALING | GENENTECH INC (US) | 2017-05-17 | — | — | EP | disclosed |
| US-20100137394-A1 | PYRAZOLE INHIBITORS OF WNT SIGNALING | GRENENTECH, INC. (US) | 2010-06-03 | — | — | US | disclosed |
| US-20100137394-A1 | PYRAZOLE INHIBITORS OF WNT SIGNALING | GRENENTECH, INC. (US) | 2010-06-03 | — | — | US | disclosed |
| US-20100137394-A1 | PYRAZOLE INHIBITORS OF WNT SIGNALING | GRENENTECH, INC. (US) | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137394-A1 | PYRAZOLE INHIBITORS OF WNT SIGNALING | WNT1, WNT3A, CTNNB1 | ALDH1A1 1479/4885HPGD 2944/4885RAB9A 624/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.