Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 10/20 | 0.45 |
| ▸ | MIF | P14174 | 4/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14037223 | 0.92 | MAOB (0.53) | ALDH1A1HPGDRAB9ASMN1; SMN2MAOB | |
| SCHEMBL3326920 | 0.84 | ALDH1A1 (0.46) | ALDH1A1HPGDRAB9ASMN1; SMN2MAOB | |
| SCHEMBL3325295 | 0.83 | MAOB (0.46) | ALDH1A1HPGDRAB9ASMN1; SMN2MAOB | |
| SCHEMBL3328483 | 0.83 | KDM4E (0.46) | ALDH1A1HPGDRAB9ASMN1; SMN2MAOB | |
| SCHEMBL3326832 | 0.80 | ALDH1A1 (0.59) | ALDH1A1HPGDRAB9ASMN1; SMN2MAOB | |
| SCHEMBL3323500 | 0.79 | ALDH1A1 (0.47) | ALDH1A1HPGDRAB9ASMN1; SMN2MAOB | |
| SCHEMBL3327514 | 0.78 | ALDH1A1 (0.51) | ALDH1A1HPGDRAB9ASMN1; SMN2MAOB | |
| SCHEMBL980255 | 0.78 | ALDH1A1 (0.46) | ALDH1A1HPGDRAB9ASMN1; SMN2MAOB | |
| SCHEMBL981737 | 0.76 | ME2 (0.51) | ALDH1A1HPGDRAB9ASMN1; SMN2MAOB | |
| SCHEMBL982457 | 0.75 | MAOB (0.49) | ALDH1A1HPGDRAB9ASMN1; SMN2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148865-B1 | PYRAZOLE INHIBITORS OF WNT SIGNALING | GENENTECH INC (US) | 2017-05-17 | — | — | EP | disclosed |
| US-20100137394-A1 | PYRAZOLE INHIBITORS OF WNT SIGNALING | GRENENTECH, INC. (US) | 2010-06-03 | — | — | US | disclosed |
| US-20100137394-A1 | PYRAZOLE INHIBITORS OF WNT SIGNALING | GRENENTECH, INC. (US) | 2010-06-03 | — | — | US | disclosed |
| US-20100137394-A1 | PYRAZOLE INHIBITORS OF WNT SIGNALING | GRENENTECH, INC. (US) | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137394-A1 | PYRAZOLE INHIBITORS OF WNT SIGNALING | WNT1, WNT3A, CTNNB1 | ALDH1A1 1479/4885HPGD 2944/4885RAB9A 624/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.