Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Phenethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.67 |
| ▸ | F2 known ✓ | P00734 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.67 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.67 |
| ▸ | HTR6 | P50406 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | GFER | P55789 | 1/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenethylamine SCHEMBL11319344 | 0.91 | HTR2A (0.73) | HTR2ACYP2A6SMN1; SMN2TAAR1LOXL2 | |
| Phenethylamine SCHEMBL7452704 | 0.90 | HTR2A (0.64) | HTR2ACYP2A6SMN1; SMN2TAAR1LOXL2 | |
| Phenethylamine SCHEMBL3721983 | 0.88 | HTR2A (0.67) | HTR2ACYP2A6SMN1; SMN2TAAR1LOXL2 | |
| Phenethylamine SCHEMBL2782147 | 0.84 | TAAR1 (0.84) | HTR2ACYP2A6SMN1; SMN2TAAR1LOXL2 | |
| Phenethylamine SCHEMBL27616397 | 0.83 | HTR2A (0.73) | HTR2ACYP2A6SMN1; SMN2TAAR1LOXL2 | |
| Phenethylamine SCHEMBL77780 | 0.83 | HTR2A (0.73) | HTR2ACYP2A6SMN1; SMN2TAAR1LOXL2 | |
| Benzylamine SCHEMBL3235132 | 0.83 | LOXL2 (0.64) | SMN1; SMN2TAAR1LOXL2HTR6KDM4E | |
| Phenethylamine SCHEMBL11321112 | 0.83 | TAAR1 (0.73) | HTR2ACYP2A6SMN1; SMN2TAAR1LOXL2 | |
| Phenethylamine SCHEMBL27806571 | 0.83 | TAAR1 (0.73) | HTR2ACYP2A6SMN1; SMN2TAAR1LOXL2 | |
| Phenethylamine SCHEMBL28351577 | 0.82 | TAAR1 (0.59) | HTR2ACYP2A6SMN1; SMN2TAAR1LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686973-A4 | COMPOSITIONS AND METHODS FOR TREATMENT OF CARDIOVASCULAR DISORDERS AND DISEASES | TECHNION RES & DEV FOUNDATION (IL) | 2009-03-25 | — | — | EP | claimed |
| EP-1942881-A2 | COMPOSITIONS AND METHODS FOR TREATMENT OF RENAL FAILURE | Technion Research and Development of Foundation, Ltd. (IL) | 2008-07-16 | — | — | EP | claimed |
| US-20080090915-A1 | METHOD FOR PREVENTING OR ATTENUATING ANTHRACYCLINE-INDUCED CARDIOTOXICITY | TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. (IL) | 2008-04-17 | — | — | US | claimed |
| WO-2007039909-A2 | COMPOSITIONS AND METHODS FOR TREATMENT OF RENAL FAILURE | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD. (IL) | 2007-04-12 | — | — | WO | claimed |
| US-20060287401-A1 | Methods for treatment of cardiovascular disorders and diseases | TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. (IL) | 2006-12-21 | — | — | US | claimed |
| EP-1686973-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF CARDIOVASCULAR DISORDERS AND DISEASES | TECHNION RESEARCH AND DEVELOPMENT FOUNDATION, LTD. (IL) | 2006-08-09 | — | — | EP | claimed |
| US-20050171210-A1 | Compositions and methods for treatment of cardiovascular disorders and diseases | TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. (IL) | 2005-08-04 | — | — | US | claimed |
| WO-2005051371-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF CARDIOVASCULAR DISORDERS AND DISEASES | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD. (IL) | 2005-06-09 | — | — | WO | claimed |
| EP-0951284-B1 | PHENYLETHYLAMINE DERIVATIVES | TEVA PHARMA (IL) | 2003-10-08 | — | — | EP | claimed |
| US-6251938-B1 | 3-(N,N-SUBSTITUTED OR UNSUBSTITUTED CARBAMYLOXY)-ALPHA.-METHYL-PHENETHYLAMINE OR SALT IS USEFUL FOR TREATING NEUROTRAUMAS, ADD, ADHD, TOURETTE'S SYNDROME, MEMORY DISORDER OR DEPRESSION | TEVA PHARMACEUTICAL INDUSTRIES, LTD., (IL) | 2001-06-26 | — | — | US | claimed |
| CN-119661597-A | Preparation method of fosfomycin trometamol | 山西双雁药业有限公司 | 2025-03-21 | — | — | CN | disclosed |
| EP-2433626-B1 | Compositions and methods for treatment of cardiovascular disorders and diseases | TECHNION RES & DEV FOUNDATION (IL) | 2015-11-04 | — | — | EP | disclosed |
| US-8263655-B2 | Methods for treatment of renal failure | TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD (IL) | 2012-09-11 | — | — | US | disclosed |
| EP-1942881-B1 | COMPOSITIONS AND METHODS FOR TREATMENT OF RENAL FAILURE | TECHNION RES AND DEV OF FOUNDATION LTD (IL) | 2012-08-08 | — | — | EP | disclosed |
| US-20120095107-A1 | METHODS FOR TREATMENT OF CARDIOVASCULAR DISORDERS AND DISEASES | RAPPAPORT FAMILY INSTITUTE FOR RESEARCH IN THE MEDICAL SCIENCES (IL) | 2012-04-19 | — | — | US | disclosed |
| WO-2005051371-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF CARDIOVASCULAR DISORDERS AND DISEASES | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD. (IL) | 2005-06-09 | — | — | WO | disclosed |
| EP-0951284-B1 | PHENYLETHYLAMINE DERIVATIVES | TEVA PHARMA (IL) | 2003-10-08 | — | — | EP | disclosed |
| EP-0951284-A4 | PHENYLETHYLAMINE DERIVATIVES | TEVA PHARMA (IL) | 2002-03-20 | — | — | EP | disclosed |
| EP-0951284-A1 | PHENYLETHYLAMINE DERIVATIVES | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1999-10-27 | — | — | EP | disclosed |
| WO-1998026775-A1 | PHENYLETHYLAMINE DERIVATIVES | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1998-06-25 | — | — | WO | disclosed |