Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8667611 | 0.88 | AKR1B1 (0.55) | AKR1B1PDE4DALDH1A1HSD17B10KDM4E | |
| SCHEMBL30093426 | 0.86 | AKR1B1 (0.53) | AKR1B1PDE4DALDH1A1HSD17B10KDM4E | |
| SCHEMBL8668157 | 0.85 | AKR1B1 (0.52) | AKR1B1PDE4DALDH1A1HSD17B10KDM4E | |
| SCHEMBL16267688 | 0.82 | AKR1B1 (0.49) | AKR1B1PDE4DALDH1A1HSD17B10TSHR | |
| SCHEMBL10418521 | 0.80 | AKR1B1 (0.41) | AKR1B1PDE4DALDH1A1HSD17B10KDM4E | |
| SCHEMBL24495462 | 0.78 | AKR1B1 (0.45) | AKR1B1PDE4DALDH1A1HSD17B10KDM4E | |
| SCHEMBL29686843 | 0.78 | AKR1B1 (0.45) | AKR1B1PDE4DALDH1A1HSD17B10KDM4E | |
| SCHEMBL4435429 | 0.78 | AKR1B1 (0.67) | AKR1B1ALDH1A1HSD17B10MAPTABCB1 | |
| SCHEMBL31446274 | 0.78 | AKR1B1 (0.67) | AKR1B1ALDH1A1HSD17B10MAPTABCB1 | |
| SCHEMBL10622242 | 0.77 | HSD17B10 (0.53) | PDE4DALDH1A1HSD17B10KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148865-B1 | PYRAZOLE INHIBITORS OF WNT SIGNALING | GENENTECH INC (US) | 2017-05-17 | — | — | EP | disclosed |
| US-20100137394-A1 | PYRAZOLE INHIBITORS OF WNT SIGNALING | GRENENTECH, INC. (US) | 2010-06-03 | — | — | US | disclosed |
| EP-2148865-A1 | PYRAZOLE INHIBITORS OF WNT SIGNALING | Genentech, Inc. (US) | 2010-02-03 | — | — | EP | disclosed |
| WO-2008137408-A1 | PYRAZOLE INHIBITORS OF WNT SIGNALING | GENENTECH, INC. (US) | 2008-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137394-A1 | PYRAZOLE INHIBITORS OF WNT SIGNALING | WNT1, WNT3A, CTNNB1 | AKR1B1 681/4885PDE4D 2470/4885ALDH1A1 1479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.