SCHEMBL8667611

SCHEMBL8667611

COc1c(Cl)ccc(Cl)c1CC(=O)O

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1B1 P15121 2/20 0.55
ALDH1A1 P00352 4/20 0.55
KDM4E B2RXH2 3/20 0.55
HSD17B10 Q99714 1/20 0.55
TSHR P16473 2/20 0.53
KMT2A Q03164 3/20 0.42
PTGS1 P23219 2/20 0.40
PTGS2 P35354 2/20 0.40
LMNA P02545 3/20 0.39
PDE4D Q08499 2/20 0.39
MEN1 O00255 2/20 0.39
CYP1A2 P05177 2/20 0.39
MAPT P10636 2/20 0.39
CYP2C9 P11712 2/20 0.39
PMP22 Q01453 2/20 0.39
HIF1A Q16665 2/20 0.39
RGS12 O14924 1/20 0.39
CYP3A4 P08684 1/20 0.39
PKM P14618 1/20 0.39
NFKB1 P19838 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30093426 0.98 AKR1B1 (0.53) AKR1B1ALDH1A1KDM4EHSD17B10TSHR
SCHEMBL3328675 0.88 AKR1B1 (0.50) AKR1B1ALDH1A1KDM4EHSD17B10TSHR
SCHEMBL27176551 0.84 ALDH1A1 (0.49) ALDH1A1KDM4EHSD17B10TSHRKMT2A
SCHEMBL18191098 0.83 AKR1B1 (0.49) AKR1B1ALDH1A1KDM4EHSD17B10TSHR
3,6 Dichloromethoxybenzoic Acid SCHEMBL9627578 0.81 ALDH1A1 (0.69) AKR1B1ALDH1A1KDM4EHSD17B10TSHR
SCHEMBL18191122 0.79 FFAR1 (0.51) ALDH1A1KDM4ETSHRKMT2APTGS1
SCHEMBL10850347 0.79 ALDH1A1 (0.44) AKR1B1ALDH1A1KDM4EHSD17B10TSHR
SCHEMBL8666827 0.79 ALDH1A1 (0.44) AKR1B1ALDH1A1KDM4EHSD17B10TSHR
SCHEMBL8668157 0.79 AKR1B1 (0.52) AKR1B1ALDH1A1KDM4EHSD17B10TSHR
SCHEMBL18191132 0.78 ALDH1A1 (0.44) ALDH1A1KDM4EHSD17B10TSHRPTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 161 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240251792-A1 WEED CONTROL METHOD SYNGENTA CROP PROTECTION AG (CH) 2024-08-01 US disclosed
EP-4340614-A1 WEED CONTROL METHOD Syngenta Crop Protection AG (CH) 2024-03-27 EP disclosed
CN-117320550-A Weed control method 先正达农作物保护股份公司 2023-12-29 CN disclosed
WO-2022243155-A1 WEED CONTROL METHOD SYNGENTA CROP PROTECTION AG (CH) 2022-11-24 WO disclosed
US-11330821-B2 Herbicidal compounds SYNGENTA PARTICIPATIONS AG (CH) 2022-05-17 US disclosed
US-11330821-B2 Herbicidal compounds SYNGENTA PARTICIPATIONS AG (CH) 2022-05-17 US disclosed
CN-107531673-B Herbicidal compounds 先正达参股股份有限公司 2020-12-08 CN disclosed
EP-3288934-B1 HERBICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2019-09-04 EP disclosed
EP-3288934-B1 HERBICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2019-09-04 EP disclosed
US-20180116219-A1 HERBICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2018-05-03 US disclosed
US-3946043-A HERBICIDES VELSICOL CHEMICAL CORPORATION (US) 1976-03-23 US disclosed
US-3946044-A HERBICIDES VELSICOL CHEMICAL CORPORATION (US) 1976-03-23 US disclosed
US-3944410-A Substituted oxadiazolidine dione herbicides VELSICOL CHEMICAL CORPORATION (US) 1976-03-16 US disclosed
US-3942972-A Dioxolane substituted α-haloanilides as herbicides VELSICOL CHEMICAL CORPORATION (US) 1976-03-09 US disclosed
US-3941580-A N,N-BIS(2-METHOXY-3,6-DICHLORO-BENZOYL-OXYALKYL) ANILINES VELSICOL CHEMICAL CORPORATION (US) 1976-03-02 US disclosed
US-3940259-A Dioxane substituted-α-haloanilides as herbicides VELSICOL CHEMICAL CORPORATION (US) 1976-02-24 US disclosed
US-3933839-A HERBICIDES VELSICOL CHEMICAL CORPORATION (US) 1976-01-20 US disclosed
US-3932410-A HERBICIDES VELSICOL CHEMICAL CORPORATION (US) 1976-01-13 US disclosed
US-3932438-A HERBICIDES VELSICOL CHEMICAL CORPORATION (US) 1976-01-13 US disclosed
US-3931209-A HERBICIDES VELSICOL CHEMICAL CORPORATION (US) 1976-01-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240251792-A1 WEED CONTROL METHOD NOTUM, WEE1, GLRX3 AKR1B1 200/4885ALDH1A1 260/4885KDM4E 985/4885
US-11330821-B2 Herbicidal compounds DDT, HPD, HDHD5 AKR1B1 500/4885ALDH1A1 258/4885KDM4E 671/4885
US-20180116219-A1 HERBICIDAL COMPOUNDS DDT, HPD, HDHD5 AKR1B1 500/4885ALDH1A1 258/4885KDM4E 671/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.