⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL342859 | 0.76 | — | — | |
| SCHEMBL5065009 | 0.76 | — | — | |
| SCHEMBL15482983 | 0.73 | — | — | |
| SCHEMBL3330778 | 0.70 | HDAC8 (0.35) | — | |
| SCHEMBL31488247 | 0.69 | CA2 (0.37) | — | |
| SCHEMBL6700545 | 0.69 | MYC (0.43) | — | |
| SCHEMBL21242477 | 0.66 | NOS1 (0.55) | — | |
| SCHEMBL31673346 | 0.66 | — | — | |
| SCHEMBL5153155 | 0.66 | — | — | |
| SCHEMBL12013263 | 0.63 | HCAR2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240391900-A1 | RIP1 KINASE INHIBITOR AND USE THEREOF | SIRONAX (BEIJING) CO., LTD. (CN) | 2024-11-28 | — | — | US | disclosed |
| CN-117957230-A | RIP1 kinase inhibitors and uses thereof | 维泰瑞隆（北京）生物科技有限公司 | 2024-04-30 | — | — | CN | disclosed |
| WO-2023040870-A1 | RIP1 KINASE INHIBITOR AND USE THEREOF | 维泰瑞隆（北京）生物科技有限公司 | 2023-03-23 | — | — | WO | disclosed |
| WO-2023039795-A1 | RIP1 KINASE INHIBITOR AND USE THEREOF | 维泰瑞隆（北京）生物科技有限公司 | 2023-03-23 | — | — | WO | disclosed |
| US-8344154-B2 | 2-thioethenyl substituted carbapenem derivatives | MEIJI SEIKA KAISHA, LTD. (JP) | 2013-01-01 | — | — | US | disclosed |
| US-20100145063-A1 | 2- thioethenyl substituted carbapenem derivatives | MARUYAMA TAKAHISA | 2010-06-10 | — | — | US | disclosed |
| US-7687490-B2 | 2-thioethenyl substituted carbapenem derivatives | MEIJI SEIKA KAISHA, LTD. (JP) | 2010-03-30 | — | — | US | disclosed |
| CN-101193891-A | 2-thioethenyl substituted carbapenem derivatives | MEIJI SEIKA KAISHA (JP) | 2008-06-04 | — | — | CN | disclosed |
| EP-1870412-A1 | 2-THIOETHENYL CARBAPENEM DERIVATIVE | MEIJI SEIKA KAISHA LTD. (JP) | 2007-12-26 | — | — | EP | disclosed |
| US-20070004700-A1 | 2-Thioethenyl substituted carbapenem derivatives | MEIJI SEIKA KAISHA, LTD. (JP) | 2007-01-04 | — | — | US | disclosed |