Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | BCL2 | P10415 | 3/20 | 0.43 |
| ▸ | BECN1 | Q14457 | 3/20 | 0.43 |
| ▸ | GLA | P06280 | 4/20 | 0.42 |
| ▸ | PKM | P14618 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3356617 | 0.82 | ALDH1A1 (0.50) | GPR119ALDH1A1HPGDSMN1; SMN2RAB9A | |
| SCHEMBL3327561 | 0.81 | PTPN2 (0.46) | GPR119ALDH1A1HPGDSMN1; SMN2RAB9A | |
| SCHEMBL3324006 | 0.80 | ALDH1A1 (0.49) | GPR119ALDH1A1GAAHPGDSMN1; SMN2 | |
| SCHEMBL3326866 | 0.76 | ALDH1A1 (0.53) | ALDH1A1MAPTKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL31110435 | 0.74 | NAMPT (0.62) | GPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL31110453 | 0.74 | NAMPT (0.62) | GPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL3328483 | 0.73 | KDM4E (0.46) | ALDH1A1KDM4EMAPTGAAKMT2A | |
| SCHEMBL3323489 | 0.72 | MAOB (0.52) | ALDH1A1KDM4EMAPTKMT2AHPGD | |
| SCHEMBL3326687 | 0.71 | KDM4E (0.46) | ALDH1A1KDM4EMAPTGAAKMT2A | |
| SCHEMBL5600152 | 0.71 | NR1H2 (0.65) | GPR119KDM4EMAPTRAB9APTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148865-B1 | PYRAZOLE INHIBITORS OF WNT SIGNALING | GENENTECH INC (US) | 2017-05-17 | — | — | EP | disclosed |
| US-20100137394-A1 | PYRAZOLE INHIBITORS OF WNT SIGNALING | GRENENTECH, INC. (US) | 2010-06-03 | — | — | US | disclosed |
| EP-2148865-A1 | PYRAZOLE INHIBITORS OF WNT SIGNALING | Genentech, Inc. (US) | 2010-02-03 | — | — | EP | disclosed |
| WO-2008137408-A1 | PYRAZOLE INHIBITORS OF WNT SIGNALING | GENENTECH, INC. (US) | 2008-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137394-A1 | PYRAZOLE INHIBITORS OF WNT SIGNALING | WNT1, WNT3A, CTNNB1 | GPR119 955/4885ALDH1A1 1479/4885KDM4E 2110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.