SCHEMBL3333154

SCHEMBL3333154

Clc1cccc(Cl)c1Cc1c(Cl)cccc1Cl

nearest known ligand 0.60

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 4/20 0.55
LMNA P02545 2/20 0.54
AKR1B1 P15121 1/20 0.50
POLB P06746 1/20 0.50
SMN1; SMN2 Q16637 2/20 0.48
CYP1A2 P05177 1/20 0.47
CYP2A6 P11509 1/20 0.47
TSHR P16473 1/20 0.47
KMT2A Q03164 1/20 0.45
GAA P10253 1/20 0.43
AR P10275 1/20 0.42
PNMT P11086 1/20 0.42
GLA P06280 1/20 0.41
HTT P42858 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
CYP2A13 Q16696 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11758388 0.81 TSHR (0.52) TAAR1LMNAAKR1B1POLBSMN1; SMN2
SCHEMBL5247984 0.81 CALM1 (0.52) TAAR1LMNAAKR1B1TSHRKMT2A
SCHEMBL673238 0.80 TAAR1 (0.70) TAAR1LMNAAKR1B1POLBSMN1; SMN2
SCHEMBL9456771 0.79 HTT (0.55) TAAR1LMNAAKR1B1POLBSMN1; SMN2
SCHEMBL27977720 0.78 TAAR1 (0.52) TAAR1LMNAAKR1B1POLBSMN1; SMN2
SCHEMBL1007397 0.78 TAAR1 (0.52) TAAR1LMNAAKR1B1POLBSMN1; SMN2
SCHEMBL18462099 0.77 TAAR1 (0.58) TAAR1LMNAAKR1B1POLBSMN1; SMN2
SCHEMBL8593028 0.77 TAAR1 (0.58) TAAR1LMNAAKR1B1POLBSMN1; SMN2
SCHEMBL2570362 0.77 TAAR1 (0.46) TAAR1LMNAAKR1B1POLBSMN1; SMN2
SCHEMBL9440191 0.75 TAAR1 (0.40) TAAR1LMNAAKR1B1POLBSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4400520-A1 CATALYST FOR OLEFIN POLYMERIZATION AND METHOD FOR PRODUCING OLEFIN POLYMER The University of Tokyo (JP) 2024-07-17 EP disclosed
WO-2023037849-A1 CATALYST FOR OLEFIN POLYMERIZATION AND METHOD FOR PRODUCING OLEFIN POLYMER 国立大学法人 東京大学 2023-03-16 WO disclosed
US-20100144872-A1 New Methylenebisphenyl Compounds Useful in the Treatment of Inflammation BIOLIPOX AB 2010-06-10 US disclosed
US-20040248963-A1 Prodrugs of excitatory amino acids ELI LILLY AND COMPANY 2004-12-09 US disclosed
US-6620940-B1 Heterocyclic nitrogen/sulfur compounds used as chemical intermediates for drugs such as 3-chloro-4-(furan-2-yl)-1,2,5 -thiadiazole ELI LILLY AND COMPANY 2003-09-16 US disclosed
US-6372945-B1 OXIDIZING BENZYL SULFIDE, REACTING BENZYL SULFOXIDE FORMED WITH STRONG BASE TO FORM BENZYLIC ANION, CONDENSING ANION WITH BENZALDEHYDE, REACTING CONDENSATION PRODUCT WITH ACID CHLORIDE TO PRODUCE ESTER, TREATING ESTER WITH STRONG BASE ELI LILLY AND COMPANY 2002-04-16 US disclosed
EP-0830356-B1 PROCESS FOR THE SYNTHESIS OF BENZO(b)THIOPHENES LILLY CO ELI (US) 2001-08-22 EP disclosed
EP-0859770-B1 PROCESS FOR THE SYNTHESIS OF BENZO b]THIOPHENES LILLY CO ELI (US) 1999-12-08 EP disclosed
US-5925680-A Synthetic excitatory amino acids ELI LILLY AND COMPANY (US) 1999-07-20 US disclosed
US-5925782-A Synthetic excitatory amino acids ELI LILLY AND COMPANY (US) 1999-07-20 US disclosed
EP-0859770-A4 1998-10-07 EP disclosed
EP-0859770-A1 PROCESS FOR THE SYNTHESIS OF BENZO b]THIOPHENES ELI LILLY AND COMPANY (US) 1998-08-26 EP disclosed
US-5750566-A NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS ELI LILLY AND COMPANY (US) 1998-05-12 US disclosed
US-5659087-A CHEMICAL INTERMEDIATES FOR 2-ARYLBENZOTHIOPHENES ELI LILLY AND COMPANY (US) 1997-08-19 US disclosed
US-5606075-A CYCLIZATION IN THE PRESENCE OF AN ACID CATALYST ELI LILLY AND COMPANY (US) 1997-02-25 US disclosed
WO-1996040676-A1 PROCESS FOR THE SYNTHESIS OF BENZO[b]THIOPHENES ELI LILLY AND COMPANY (US) 1996-12-19 WO disclosed
US-5569772-A CHEMICAL INTERMEDIATES ELI LILLY AND COMPANY (US) 1996-10-29 US disclosed
US-5514826-A INTERMEDIATES FOR 2-ARYLBENZO(B)THIOPHENES ELI LILLY AND COMPANY (US) 1996-05-07 US disclosed
US-5512701-A REACTING SULFOXIDE DERIVATIVE WITH A SILYATING AGENT TO FORM SULFENATE SILYL ESTER, OPTIONALLY REACTING INTERMEDIATE WITH AN AMINE AND/OR A MERCAPTAN ELI LILLY AND COMPANY (US) 1996-04-30 US disclosed
EP-0696577-A1 Synthetic excitatory amino acids ELI LILLY AND COMPANY (US) 1996-02-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040248963-A1 Prodrugs of excitatory amino acids SLC1A2, SLC1A1, SLC1A3 TAAR1 172/4885LMNA 4003/4885AKR1B1 1113/4885
US-20100144872-A1 New Methylenebisphenyl Compounds Useful in the Treatment of Inflammation LTC4S, LTB4R2, LTB4R TAAR1 1435/4885LMNA 1200/4885AKR1B1 498/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.