Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Silver. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | BBOX1 | O75936 | 4/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | CTSG | P08311 | 1/20 | 0.31 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.31 |
| ▸ | CMA1 | P23946 | 1/20 | 0.31 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL1100579 | 0.97 | CA1 (0.38) | CA1NFKB1BBOX1CA2PRSS1 | |
| SCHEMBL620277 | 0.83 | TSHR (0.42) | NFKB1 | |
| SCHEMBL4605980 | 0.81 | TSHR (0.41) | — | |
| SCHEMBL1114582 | 0.79 | CA2 (0.48) | CA1CA2PRSS1CTSGCTRB1 | |
| SCHEMBL8645646 | 0.78 | TSHR (0.41) | NFKB1GPR84 | |
| SCHEMBL22573795 | 0.77 | PRSS1 (0.46) | CA1CA2PRSS1CTSGCTRB1 | |
| SCHEMBL22190520 | 0.77 | ALDH1A1 (0.43) | NFKB1GPR84 | |
| SCHEMBL21580900 | 0.77 | TSHR (0.45) | PRSS1CTSGCTRB1CMA1 | |
| SCHEMBL7613397 | 0.76 | ZDHHC7 (0.47) | CA1CA2PRSS1CTSGCTRB1 | |
| SCHEMBL5167002 | 0.76 | ZDHHC7 (0.47) | CA1CA2PRSS1CTSGCTRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100143608-A1 | METHOD AND DEVICE FOR PREPARING A MULTILAYER COATING ON A SUBSTRATE | COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) | 2010-06-10 | — | — | US | disclosed |