Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | RAC1 | P63000 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3331683 | 0.93 | CYP1A2 (0.43) | IKBKBCYP1A2CYP2A6ALDH1A1CYP2C9 | |
| SCHEMBL3333863 | 0.86 | IKBKB (0.38) | IKBKBCYP1A2CYP2A6ALDH1A1CYP2C9 | |
| SCHEMBL3338724 | 0.84 | RAC1 (0.39) | IKBKBCYP1A2CYP2A6ALDH1A1CYP2C9 | |
| SCHEMBL3311229 | 0.81 | RAPGEF4 (0.35) | SMN1; SMN2SRCCYP11B1CYP11B2 | |
| SCHEMBL3313721 | 0.80 | RAB9A (0.37) | IKBKBALDH1A1TSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL3331310 | 0.76 | RAC1 (0.39) | IKBKBCYP1A2CYP2A6ALDH1A1CYP2C9 | |
| SCHEMBL3334292 | 0.76 | IKBKB (0.45) | IKBKBCYP1A2CYP2A6ESR1ESR2 | |
| SCHEMBL13165373 | 0.76 | MAOB (0.45) | SMN1; SMN2 | |
| SCHEMBL3334028 | 0.74 | SMN1; SMN2 (0.45) | IKBKBCYP1A2ALDH1A1CYP2C9HPGD | |
| SCHEMBL3971627 | 0.73 | RAB9A (0.39) | IKBKBALDH1A1TSHRSMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144674-A1 | PYRIDAZINE DERIVATIVES | SYNGENTA CROP PROTECTION, INC. (US) | 2010-06-10 | — | — | US | claimed |
| EP-2077997-A1 | PYRIDAZINE DERIVATIVES | Syngeta Participations AG (CH) | 2009-07-15 | — | — | EP | claimed |
| WO-2008049585-A1 | PYRIDAZINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2008-05-02 | — | — | WO | claimed |
| US-20100144674-A1 | PYRIDAZINE DERIVATIVES | SYNGENTA CROP PROTECTION, INC. (US) | 2010-06-10 | — | — | US | disclosed |
| EP-2077997-A1 | PYRIDAZINE DERIVATIVES | Syngeta Participations AG (CH) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008049585-A1 | PYRIDAZINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2008-05-02 | — | — | WO | disclosed |
| EP-1916240-A1 | Pyridazine derivatives | Syngeta Participations AG (CH) | 2008-04-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144674-A1 | PYRIDAZINE DERIVATIVES | C3AR1, C1S, CBR3 | IKBKB 4112/4885CYP1A2 203/4885CYP2A6 763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.