Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.31 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.30 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3966184 | 0.92 | RAPGEF4 (0.38) | RAPGEF4GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL3313721 | 0.89 | RAB9A (0.37) | RAPGEF4GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL1873945 | 0.84 | KMT2A (0.34) | RAPGEF4GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL3971627 | 0.82 | RAB9A (0.39) | RAPGEF4GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL3334563 | 0.81 | IKBKB (0.40) | SMN1; SMN2SRCCYP11B1CYP11B2 | |
| SCHEMBL3311645 | 0.81 | ERBB2 (0.37) | RAPGEF4RAB9ANPC1CYP11B1CYP11B2 | |
| SCHEMBL3582802 | 0.79 | NPC1 (0.38) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL1043323 | 0.78 | ACHE (0.48) | RAPGEF4MEN1KMT2ASMN1; SMN2ACHE | |
| SCHEMBL1869939 | 0.78 | RAB9A (0.36) | RAPGEF4GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL13165373 | 0.78 | MAOB (0.45) | RAPGEF4RAB9AMEN1NPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100113457-A1 | NOVEL PYRIDAZINE DERIVATIVES | SYNGENTA CROP PROTECTION, INC. (US) | 2010-05-06 | — | — | US | claimed |
| EP-2121629-A1 | NOVEL PYRIDAZINE DERIVATIVES | Syngeta Participations AG (CH) | 2009-11-25 | — | — | EP | claimed |
| WO-2008049584-A1 | NOVEL PYRIDAZINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2008-05-02 | — | — | WO | claimed |
| US-20100113457-A1 | NOVEL PYRIDAZINE DERIVATIVES | SYNGENTA CROP PROTECTION, INC. (US) | 2010-05-06 | — | — | US | disclosed |
| EP-2121629-A1 | NOVEL PYRIDAZINE DERIVATIVES | Syngeta Participations AG (CH) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008049584-A1 | NOVEL PYRIDAZINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2008-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113457-A1 | NOVEL PYRIDAZINE DERIVATIVES | C3AR1, C5, C1S | RAPGEF4 3305/4885GABRA1 4254/4885GABRG2 4102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.