Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 12/20 | 0.81 |
| ▸ | RAB9A | P51151 | 5/20 | 0.64 |
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | MMP13 | P45452 | 3/20 | 0.56 |
| ▸ | MMP2 | P08253 | 3/20 | 0.56 |
| ▸ | MMP9 | P14780 | 3/20 | 0.56 |
| ▸ | MMP8 | P22894 | 3/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.54 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.54 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26731641 | 0.90 | NPBWR1 (1.00) | NPBWR1RAB9AMAPTSMN1; SMN2HTT | |
| SCHEMBL28761269 | 0.89 | RAB9A (0.80) | NPBWR1RAB9AMAPTSMN1; SMN2HTT | |
| SCHEMBL7386711 | 0.86 | RAB9A (0.66) | NPBWR1RAB9AMAPTSMN1; SMN2HTT | |
| SCHEMBL3193088 | 0.85 | NPBWR1 (0.80) | NPBWR1RAB9AMAPTSMN1; SMN2HTT | |
| SCHEMBL2308775 | 0.85 | NPBWR1 (0.79) | NPBWR1RAB9AMAPTSMN1; SMN2HTT | |
| SCHEMBL14447531 | 0.85 | RAB9A (0.64) | NPBWR1RAB9AMAPTSMN1; SMN2HTT | |
| SCHEMBL3190872 | 0.83 | NPBWR1 (0.65) | NPBWR1RAB9AMAPTSMN1; SMN2HTT | |
| SCHEMBL5758635 | 0.83 | NPBWR1 (0.71) | NPBWR1RAB9AMAPTSMN1; SMN2HTT | |
| SCHEMBL5566197 | 0.82 | NPC1 (0.78) | NPBWR1RAB9AMAPTSMN1; SMN2HTT | |
| SCHEMBL3336441 | 0.82 | KDM4E (0.59) | NPBWR1RAB9AMAPTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12528793-B2 | Compounds for treating tuberculosis | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2026-01-20 | — | — | US | disclosed |
| CN-115380029-B | Compounds for the treatment of tuberculosis | 南洋理工大学 | 2025-06-17 | — | — | CN | disclosed |
| US-20230348436-A1 | COMPOUNDS FOR TREATING TUBERCULOSIS | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2023-11-02 | — | — | US | disclosed |
| CN-115380029-A | Compounds for the treatment of tuberculosis | 南洋理工大学 | 2022-11-22 | — | — | CN | disclosed |
| US-8198307-B2 | Imidazole derivatives having aryl piperidine substituent, method for preparation thereof and pharmaceutical compositions containing same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2012-06-12 | — | — | US | disclosed |
| US-20100145054-A1 | IMIDAZOLE DERIVATIVES HAVING ARYL PIPERIDINE SUBSTITUENT, METHOD FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2010-06-10 | — | — | US | disclosed |
| WO-2008140239-A1 | IMIDAZOLE DERIVATIVES HAVING ARYL PIPERIDINE SUBSTITUENT, METHOD FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2008-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230348436-A1 | COMPOUNDS FOR TREATING TUBERCULOSIS | DOT1L, HAT1, UQCRB | NPBWR1 1416/4885RAB9A 1643/4885MAPT 2454/4885 |
| US-12528793-B2 | Compounds for treating tuberculosis | TPMT, UQCRB, ARG1 | NPBWR1 2870/4885RAB9A 1872/4885MAPT 2743/4885 |
| US-20100145054-A1 | IMIDAZOLE DERIVATIVES HAVING ARYL PIPERIDINE SUBSTITUENT, METHOD FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | TYR, MCHR1, MCHR2 | NPBWR1 560/4885RAB9A 687/4885MAPT 685/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.