SCHEMBL3336349

SCHEMBL3336349

Fc1c(C(F)(F)F)ccc(Cl)c1Cl

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 8/20 0.39
IDO1 P14902 2/20 0.36
HTR3E A5X5Y0 1/20 0.36
HTR3B O95264 1/20 0.36
HTR3A P46098 1/20 0.36
HTR3D Q70Z44 1/20 0.36
HTR3C Q8WXA8 1/20 0.36
KDR P35968 1/20 0.36
CLCN2 P51788 1/20 0.35
P2RX7 Q99572 1/20 0.33
PDE2A O00408 1/20 0.33
HTR2A P28223 1/20 0.33
HTR2C P28335 1/20 0.33
HTR2B P41595 1/20 0.33
EPAS1 Q99814 1/20 0.33
RAPGEF4 Q8WZA2 1/20 0.33
PDK1 Q15118 1/20 0.33
CYP3A4 P08684 1/20 0.32
MAPK1 P28482 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1580214 0.81 NOTUM (0.39) NOTUMIDO1HTR3EHTR3BHTR3A
SCHEMBL30524328 0.81 EPAS1 (0.36) NOTUMP2RX7PDE2AHTR2AHTR2C
SCHEMBL8664297 0.81 TSHR (0.43) NOTUMCYP3A4MAPK1
SCHEMBL8159986 0.81 EPAS1 (0.36) NOTUMP2RX7PDE2AHTR2AHTR2C
SCHEMBL2991016 0.80 NOTUM (0.41) NOTUMIDO1HTR3EHTR3BHTR3A
SCHEMBL30524329 0.80 NOTUM (0.41) NOTUMIDO1HTR3EHTR3BHTR3A
SCHEMBL20653185 0.79 CYP3A4 (0.31) HTR2AHTR2CHTR2BCYP3A4MAPK1
SCHEMBL31295797 0.77 KIF11 (0.37) IDO1HTR3EHTR3BHTR3AHTR3D
SCHEMBL31561613 0.77 CSNK2A2 (0.44) HTR3EHTR3BHTR3AHTR3DHTR3C
SCHEMBL10696453 0.77 CSNK2A2 (0.44) HTR3EHTR3BHTR3AHTR3DHTR3C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-219701894-U Chlorination kettle 阜新宇泽化工有限公司 2023-09-19 CN disclosed
CN-219709142-U Industrial wastewater treatment device 阜新宇泽化工有限公司 2023-09-19 CN disclosed
US-20100096585-A1 Process for Preparing 2,6-Dichloro-4-(Trifluoromethyl)Phenylhydrazine Using Mixtures of Dichloro-Fluoro-Trifluoromethylbenzenes BASF SE (DE) 2010-04-22 US disclosed
US-20100096585-A1 Process for Preparing 2,6-Dichloro-4-(Trifluoromethyl)Phenylhydrazine Using Mixtures of Dichloro-Fluoro-Trifluoromethylbenzenes BASF SE (DE) 2010-04-22 US disclosed
CN-101631767-A Process for preparing 2,6-dichloro-4-(trifluoromethyl)phenylhydrazine using mixtures of dichloro-fluoro-trifluoromethylbenzenes BASF SE 2010-01-20 CN disclosed
EP-2137135-A1 PROCESS FOR PREPARING 2,6-DICHLORO-4-(TRIFLUOROMETHYL)PHENYLHYDRAZINE USING MIXTURES OF DICHLORO-FLUORO-TRIFLUOROMETHYLBENZENES BASF SE (DE) 2009-12-30 EP disclosed
WO-2008113660-A1 PROCESS FOR PREPARING 2,6-DICHLORO-4-(TRIFLUOROMETHYL)PHENYLHYDRAZINE USING MIXTURES OF DICHLORO-FLUORO-TRIFLUOROMETHYLBENZENES BASF SE (DE) 2008-09-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100096585-A1 Process for Preparing 2,6-Dichloro-4-(Trifluoromethyl)Phenylhydrazine Using Mixtures of Dichloro-Fluoro-Trifluoromethylbenzenes DAZAP1, CYP4Z1, CYP2F1 NOTUM 2607/4885IDO1 1460/4885HTR3E 2445/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.