Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.58 |
| ▸ | LMNA | P02545 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | HTT | P42858 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.53 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7913514 | 0.81 | NPC1 (0.80) | MAPTLMNAKDM4EHTTNPC1 | |
| SCHEMBL8204503 | 0.81 | NPC1 (0.80) | MAPTLMNAKDM4EHTTNPC1 | |
| SCHEMBL3336655 | 0.77 | NPC1 (0.57) | MAPTLMNAKDM4EHTTNPC1 | |
| SCHEMBL1031711 | 0.77 | MAPT (0.58) | MAPTLMNAKDM4EHTTNPC1 | |
| SCHEMBL17771965 | 0.77 | NPC1 (0.57) | MAPTLMNAKDM4EHTTNPC1 | |
| SCHEMBL23511143 | 0.77 | FTO (0.79) | MAPTLMNAKDM4EHTTNPC1 | |
| SCHEMBL12565720 | 0.77 | FTO (0.79) | MAPTLMNAKDM4EHTTNPC1 | |
| SCHEMBL1485811 | 0.76 | TDP1 (0.42) | MAPTLMNAKDM4EHTTNPC1 | |
| SCHEMBL16434726 | 0.76 | FTO (0.56) | MAPTLMNAKDM4EHTTNPC1 | |
| SCHEMBL14538303 | 0.73 | NPC1 (0.57) | MAPTLMNAKDM4EHTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5326697-A | NAD, hydroxybutyrate dehydrogenase, cystine reductase, cystine indicator dye | MILES INC. (US) | 1994-07-05 | — | — | US | claimed |
| EP-0348826-B1 | Isobenzothiazolone chromogenic thiol indicators and their derivatives | MILES INC (US) | 1994-04-13 | — | — | EP | claimed |
| US-5187265-A | Medical diagnosis | MILES INC. (US) | 1993-02-16 | — | — | US | claimed |
| US-5187105-A | Process for determining thiols using chromogenic benzoisothiazolone derivatives | MILES INC. (US) | 1993-02-16 | — | — | US | claimed |
| US-5128457-A | Medical diagnosis | MILES INC. (US) | 1992-07-07 | — | — | US | claimed |
| EP-0348826-A2 | Isobenzothiazolone chromogenic thiol indicators and their derivatives | MILES INC. (US) | 1990-01-03 | — | — | EP | claimed |
| US-20180311237-A1 | COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING MUCOSITIS AND WEIGHT LOSS | ZPNE GROUP GMBH (CH) | 2018-11-01 | — | — | US | disclosed |
| US-20150031701-A1 | COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING MUCOSITIS AND WEIGHT LOSS | ZPNE GROUP GMBH (CH) | 2015-01-29 | — | — | US | disclosed |
| US-20130259930-A1 | Compositions and Methods for Preventing and Treating Mucositis and Weight Loss | CASCADE ESTATE LTD. (MU) | 2013-10-03 | — | — | US | disclosed |
| US-20120196825-A1 | COMPOSITIONS AND METHODS FOR MODULATING THE IMMUNE SYSTEM | SUPPORTIVE THERAPEUTICS AG (CH) | 2012-08-02 | — | — | US | disclosed |
| US-20100092547-A1 | COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING MUCOSITIS AND WEIGHT LOSS | ZPNE GROUP GMBH (CH) | 2010-04-15 | — | — | US | disclosed |
| EP-2134347-A2 | COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING MUCOSITIS AND WEIGHT LOSS | Prendergast, Patrick T. (AU) | 2009-12-23 | — | — | EP | disclosed |
| US-20090156546-A1 | Compositions and methods for modulating the immune system | SUPPORTIVE THERAPEUTICS AG (CH) | 2009-06-18 | — | — | US | disclosed |
| US-5190863-A | Composition for determining the presence or concentration of D-β-hydroxybutyrate | MILES INC. (US) | 1993-03-02 | — | — | US | disclosed |
| US-5187265-A | Medical diagnosis | MILES INC. (US) | 1993-02-16 | — | — | US | disclosed |
| US-5187105-A | Process for determining thiols using chromogenic benzoisothiazolone derivatives | MILES INC. (US) | 1993-02-16 | — | — | US | disclosed |
| US-5130433-A | Indicators for detection of thiol | MILES INC. (US) | 1992-07-14 | — | — | US | disclosed |
| US-5128457-A | Medical diagnosis | MILES INC. (US) | 1992-07-07 | — | — | US | disclosed |
| EP-0463524-A1 | Composition and method of assaying for ketone bodies | Bayer Corporation (US) | 1992-01-02 | — | — | EP | disclosed |
| EP-0348826-A2 | Isobenzothiazolone chromogenic thiol indicators and their derivatives | MILES INC. (US) | 1990-01-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180311237-A1 | COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING MUCOSITIS AND WEIGHT LOSS | SI, MTPN, MUC1 | MAPT 4455/4885LMNA 1232/4885KDM4E 2898/4885 |
| US-20100092547-A1 | COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING MUCOSITIS AND WEIGHT LOSS | MTAP, TPMT, MUC1 | MAPT 4845/4885LMNA 2322/4885KDM4E 3627/4885 |
| US-20150031701-A1 | COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING MUCOSITIS AND WEIGHT LOSS | SI, MTPN, MUC1 | MAPT 4455/4885LMNA 1232/4885KDM4E 2898/4885 |
| US-20130259930-A1 | Compositions and Methods for Preventing and Treating Mucositis and Weight Loss | SI, MTPN, MUC1 | MAPT 4455/4885LMNA 1232/4885KDM4E 2898/4885 |
| US-20090156546-A1 | Compositions and methods for modulating the immune system | MRE11, XPA, MPL | MAPT 4639/4885LMNA 2572/4885KDM4E 3900/4885 |
| US-20120196825-A1 | COMPOSITIONS AND METHODS FOR MODULATING THE IMMUNE SYSTEM | MRE11, XPA, MPL | MAPT 4639/4885LMNA 2572/4885KDM4E 3900/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.