Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Hydroxystilbamidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 known ✓ | P00734 | 6/20 | 0.39 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.77 |
| ▸ | POLB | P06746 | 1/20 | 0.77 |
| ▸ | MAPT | P10636 | 1/20 | 0.77 |
| ▸ | RAD52 | P43351 | 1/20 | 0.77 |
| ▸ | UBE2N | P61088 | 1/20 | 0.77 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.77 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.53 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | PLAU | P00749 | 5/20 | 0.43 |
| ▸ | PLAT | P00750 | 3/20 | 0.43 |
| ▸ | PLG | P00747 | 2/20 | 0.43 |
| ▸ | KLK1 | P06870 | 2/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydroxystilbamidine SCHEMBL17224190 | 1.00 | KDM4E (0.77) | KDM4EPOLBMAPTRAD52UBE2N | |
| Hydroxystilbamidine SCHEMBL26114123 | 1.00 | KDM4E (0.77) | KDM4EPOLBMAPTRAD52UBE2N | |
| Hydroxystilbamidine SCHEMBL108492 | 0.90 | KDM4E (0.72) | KDM4EPOLBMAPTRAD52UBE2N | |
| Hydroxystilbamidine SCHEMBL8482349 | 0.90 | KDM4E (0.72) | KDM4EPOLBMAPTRAD52UBE2N | |
| Hydroxystilbamidine SCHEMBL29439031 | 0.90 | KDM4E (0.72) | KDM4EPOLBMAPTRAD52UBE2N | |
| Hydroxystilbamidine SCHEMBL31614578 | 0.90 | KDM4E (0.72) | KDM4EPOLBMAPTRAD52UBE2N | |
| Hydroxystilbamidine SCHEMBL554644 | 0.87 | POLB (1.00) | KDM4EPOLBMAPTRAD52UBE2N | |
| Hydroxystilbamidine SCHEMBL10621745 | 0.87 | POLB (1.00) | KDM4EPOLBMAPTRAD52UBE2N | |
| Hydroxystilbamidine SCHEMBL10621740 | 0.87 | POLB (1.00) | KDM4EPOLBMAPTRAD52UBE2N | |
| Hydroxystilbamidine SCHEMBL27618664 | 0.85 | KDM4E (0.67) | KDM4EPOLBMAPTRAD52UBE2N |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130073011-A1 | METHOD FOR TREATING A PATIENT HAVING A SPINAL CORD INJURY USING PHOTOTHERAPY | Henry M. Jackson Foundation for Advancement of Military Medicine (US) | 2013-03-21 | — | — | US | disclosed |
| US-8328857-B2 | Method for treating a patient having a spinal cord injury using phototherapy | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2012-12-11 | — | — | US | disclosed |
| US-20100152820-A1 | METHOD FOR TREATING A PATIENT HAVING A SPINAL CORD INJURY USING PHOTOTHERAPY | ANDERS JUANITA J | 2010-06-17 | — | — | US | disclosed |
| US-7695504-B2 | Method for regeneration and functional recovery after spinal cord injury using phototherapy | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2010-04-13 | — | — | US | disclosed |
| US-20080287381-A1 | Injectable Agent for the Targeted Treatment of Retinal Ganglion Cells | EBERHARD-KARLS-UNIVERSITAT TUBINGEN UNIVERSITATSKLINIKUM (DE) | 2008-11-20 | — | — | US | disclosed |
| US-20080103562-A1 | METHOD FOR REGENERATION AND FUNCTIONAL RECOVERY AFTER SPINAL CORD INJURY USING PHOTOTHERAPY | PHOTOTHERA, INC. | 2008-05-01 | — | — | US | disclosed |
| US-7344555-B2 | Light promotes regeneration and functional recovery after spinal cord injury | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2008-03-18 | — | — | US | disclosed |
| US-20060036299-A1 | Light promotes regeneration and functional recovery after spinal cord injury | HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE | 2006-02-16 | — | — | US | disclosed |