Hydroxystilbamidine

Hydroxystilbamidine

SCHEMBL554644

N=C(N)c1ccc(/C=C/c2ccc(C(=N)N)cc2O)cc1.O=S(=O)(O)CCO.O=S(=O)(O)CCO

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 3/20 1.00
KDM4E B2RXH2 2/20 1.00
MAPT P10636 2/20 1.00
RAD52 P43351 1/20 1.00
UBE2N P61088 1/20 1.00
NPSR1 Q6W5P4 1/20 1.00
ALDH1A1 P00352 3/20 0.50
LMNA P02545 2/20 0.50
RAB9A P51151 2/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
NPC1 O15118 1/20 0.50
ALOX15 P16050 1/20 0.50
BRCA1 P38398 1/20 0.50
HTT P42858 1/20 0.50
GMNN O75496 1/20 0.50
PKM P14618 1/20 0.50
THPO P40225 1/20 0.50
MTOR P42345 1/20 0.50
RECQL P46063 1/20 0.50
BLM P54132 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydroxystilbamidine SCHEMBL10621745 1.00 POLB (1.00) POLBKDM4EMAPTRAD52UBE2N
Hydroxystilbamidine SCHEMBL10621740 1.00 POLB (1.00) POLBKDM4EMAPTRAD52UBE2N
Stilbamidine SCHEMBL20787646 0.88 POLB (0.78) POLBKDM4EMAPTRAD52UBE2N
Stilbamidine SCHEMBL3934275 0.88 POLB (0.78) POLBKDM4EMAPTRAD52UBE2N
Hydroxystilbamidine SCHEMBL3338013 0.87 KDM4E (0.77) POLBKDM4EMAPTRAD52UBE2N
Hydroxystilbamidine SCHEMBL17224190 0.87 KDM4E (0.77) POLBKDM4EMAPTRAD52UBE2N
Hydroxystilbamidine SCHEMBL26114123 0.87 KDM4E (0.77) POLBKDM4EMAPTRAD52UBE2N
Hydroxystilbamidine SCHEMBL31614578 0.85 KDM4E (0.72) POLBKDM4EMAPTRAD52UBE2N
Hydroxystilbamidine SCHEMBL29439031 0.85 KDM4E (0.72) POLBKDM4EMAPTRAD52UBE2N
Hydroxystilbamidine SCHEMBL108492 0.85 KDM4E (0.72) POLBKDM4EMAPTRAD52UBE2N

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 128 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025111482-A1 COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS BEXSON BIOMEDICAL, INC. (US) 2025-05-30 WO claimed
US-8026285-B2 Control release of biologically active compounds from multi-armed oligomers BEZWADA BIOMEDICAL, LLC (US) 2011-09-27 US claimed
US-20090076174-A1 CONTROL RELEASE OF BIOLOGICALLY ACTIVE COMPOUNDS FROM MULTI-ARMED OLIGOMERS BEZWADA BIOMEDICAL, LLC (US) 2009-03-19 US claimed
JP-2003514875-A 2003-04-22 JP claimed
EP-1231948-A1 A PROPELLANT FREE SPRAY-ON SKIN PATCH COMPOSITION FOR IMPROVING WOUND HEALING AND FOR DRUG ADMINISTRATION Ever Power Holding Inc. (VG) 2002-08-21 EP claimed
WO-2001037890-A1 A PROPELLANT FREE SPRAY-ON SKIN PATCH COMPOSITION FOR IMPROVING WOUND HEALING AND FOR DRUG ADMINISTRATION EVER POWER HOLDING INC (VG) 2001-05-31 WO claimed
US-6224848-B1 Pharmaceuticals providing diagnosis and selective tissue necrosis using Mossbauer absorber atom MILLS RANDELL L (US) 2001-05-01 US claimed
WO-2025111482-A1 COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS BEXSON BIOMEDICAL, INC. (US) 2025-05-30 WO disclosed
EP-3356440-B1 HYDROPHOBIC HIGHLY BRANCHED CARBOHYDRATE POLYMERS PURDUE RESEARCH FOUNDATION (US) 2024-06-05 EP disclosed
EP-3681504-B1 METHODS OF DETECTION USING X-RAY FLUORESCENCE ICAGEN INC (US) 2023-08-23 EP disclosed
US-11573224-B2 Methods of detection using X-ray fluorescence ICAGEN, LLC (US) 2023-02-07 US disclosed
US-20220257770-A1 HYDROPHOBIC HIGHLY BRANCHED CARBOHYDRATE POLYMERS PURDUE RESEARCH FOUNDATION (US) 2022-08-18 US disclosed
US-20210290771-A1 ENGINEERED RECEPTOR/LIGAND SYSTEM FOR DELIVERY OF THERAPEUTIC AGENTS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2021-09-23 US disclosed
WO-1989003208-A1 POLYENE MACROLIDE PRE-LIPOSOMAL POWDERS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1989-04-20 WO disclosed
US-4812312-A ADMINISTERING BY INJECTION TO TREAT SYSTEMIC FUNGAL INFECTIONS BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 1989-03-14 US disclosed
WO-1988006440-A2 LIPOSOME-INCORPORATED NYSTATIN BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1988-09-07 WO disclosed
US-4632981-A Human antithrombin III GENENTECH, INC. (US) 1986-12-30 US disclosed
US-4517294-A CLONING BVEHICLES FOR DNA SEQUENCE GENENTECH, INC. (US) 1985-05-14 US disclosed
EP-0090505-A2 Human antithrombin III, DNA sequences therefor, expression vehicles and cloning vectors containing such sequences and cell cultures transformed thereby, a process for expressing human antithrombin III, and pharmaceutical compositions comprising it GENENTECH, INC. (US) 1983-10-05 EP disclosed
US-3946734-A APPARATUS FOR CONTROLLING THE RELEASE OF A DRUG THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF STATE (US) 1976-03-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090076174-A1 CONTROL RELEASE OF BIOLOGICALLY ACTIVE COMPOUNDS FROM MULTI-ARMED OLIGOMERS MME, CTSA, ALG1 POLB 1563/4885KDM4E 3828/4885MAPT 869/4885
US-20220257770-A1 HYDROPHOBIC HIGHLY BRANCHED CARBOHYDRATE POLYMERS HACD3, ALG1, HACD2 POLB 3423/4885KDM4E 4796/4885MAPT 1847/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.