Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.61 |
| ▸ | F10 | P00742 | 1/20 | 0.61 |
| ▸ | F7 | P08709 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.57 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15552138 | 0.83 | GAA (0.55) | GAANPC1RAB9ALMNAEGFR | |
| SCHEMBL24520481 | 0.83 | POLB (0.68) | NPC1RAB9ALMNACYP1A2CYP2E1 | |
| SCHEMBL13947376 | 0.82 | F2 (0.64) | F2F10F7GAANPC1 | |
| SCHEMBL230024 | 0.82 | GAA (0.78) | F2F10F7GAANPC1 | |
| SCHEMBL15778057 | 0.81 | BCHE (0.65) | GAANPC1RAB9ALMNACYP1A2 | |
| SCHEMBL6994153 | 0.79 | GAA (0.58) | F2F10F7GAANPC1 | |
| SCHEMBL6994149 | 0.79 | GAA (0.58) | F2F10F7GAANPC1 | |
| SCHEMBL13909540 | 0.77 | CXCR4 (0.58) | GAANPC1RAB9ALMNACYP1A2 | |
| SCHEMBL7409704 | 0.77 | F10 (1.00) | F2F10F7 | |
| SCHEMBL6162109 | 0.77 | F10 (0.82) | F2F10F7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189889-B1 | COMPOSITIONS AND METHODS FOR INHIBITING CELL DEATH | ELAN PHARMA INT LTD (IE) | 2003-12-17 | — | — | EP | claimed |
| EP-0201575-B1 | NEW PICOLINE DERIVATIVES, PREPARATION PROCESS THEREOF, UTILIZATION THEREOF AND DRUGS CONTAINING THEM | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1992-08-12 | — | — | EP | claimed |
| US-8198307-B2 | Imidazole derivatives having aryl piperidine substituent, method for preparation thereof and pharmaceutical compositions containing same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2012-06-12 | — | — | US | disclosed |
| US-20100145054-A1 | IMIDAZOLE DERIVATIVES HAVING ARYL PIPERIDINE SUBSTITUENT, METHOD FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2010-06-10 | — | — | US | disclosed |
| US-7528251-B2 | Method for enantioselective preparation of sulphoxide derivatives | SIDEM PHARMA SA (LU) | 2009-05-05 | — | — | US | disclosed |
| EP-1802620-B1 | METHOD FOR ENANTIOSELECTIVE PREPARATION OF SULPHOXIDE DERIVATIVES | SIDEM PHARMA S A (LU) | 2008-12-17 | — | — | EP | disclosed |
| US-20070299261-A1 | Method For Enantioselective Preparation Of Sulphoxide Derivatives | SIDEM PHARMA SA (LU) | 2007-12-27 | — | — | US | disclosed |
| EP-1802620-A1 | METHOD FOR ENANTIOSELECTIVE PREPARATION OF SULPHOXIDE DERIVATIVES | Sidem Pharma (LU) | 2007-07-04 | — | — | EP | disclosed |
| EP-1740571-A1 | A PROCESS FOR PREPARING PYRIDINYLMETHYL-1H- BENZIMIDAZOLE COMPOUNDS IN ENANTIOMERICALLY ENRICHED FORM OR AS SINGLE ENANTIOMERS | Hetero Drugs Limited (IN) | 2007-01-10 | — | — | EP | disclosed |
| WO-2006037894-A1 | METHOD FOR ENANTIOSELECTIVE PREPARATION OF SULPHOXIDE DERIVATIVES | SIDEM PHARMA S.A. (LU) | 2006-04-13 | — | — | WO | disclosed |
| WO-2005105786-A1 | A PROCESS FOR PREPARING PYRIDINYLMETHYL-1H- BENZIMIDAZOLE COMPOUNDS IN ENANTIOMERICALLY ENRICHED FORM OR AS SINGLE ENANTIOMERS | HETERO DRUGS LIMITED (IN) | 2005-11-10 | — | — | WO | disclosed |
| US-6541486-B1 | Used for treating ischemia, such as results from stroke or myocardial infarction, trauma, neurodegeneration, and inflammation. | ELAN PHARMA INTERNATIONAL LTD. (IE) | 2003-04-01 | — | — | US | disclosed |
| US-4686230-A | Picoline derivative useful as gastric acid secretion inhibitors | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1987-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299261-A1 | Method For Enantioselective Preparation Of Sulphoxide Derivatives | TST, ADH1A, ADH1C | F2 397/4885F10 1387/4885F7 564/4885 |
| US-20100145054-A1 | IMIDAZOLE DERIVATIVES HAVING ARYL PIPERIDINE SUBSTITUENT, METHOD FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | TYR, MCHR1, MCHR2 | F2 4715/4885F10 4170/4885F7 3110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.