Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 9/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3343807 | 0.84 | HTR7 (0.41) | HTR7TACR1ADAMTS5 | |
| SCHEMBL5408982 | 0.80 | TACR1 (0.57) | ALDH1A1TDP1MAPTHTR7TACR1 | |
| SCHEMBL5390992 | 0.78 | MAPT (0.44) | ALDH1A1TDP1MAPTMEN1KMT2A | |
| SCHEMBL13302135 | 0.76 | NPC1 (0.46) | ALDH1A1PKMMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3341938 | 0.75 | ALDH1A1 (0.42) | ALDH1A1TDP1MAPTHTR7PKM | |
| SCHEMBL3436603 | 0.75 | ALDH1A1 (0.60) | ALDH1A1TDP1MAPTPKMATM | |
| SCHEMBL3648193 | 0.75 | L3MBTL1 (0.48) | ALDH1A1TDP1ATMTSHRMEN1 | |
| SCHEMBL6687029 | 0.74 | TACR1 (0.49) | TACR1CYP2D6 | |
| SCHEMBL3652600 | 0.72 | ALDH1A1 (0.48) | ALDH1A1MAPTPKMTSHRMEN1 | |
| SCHEMBL6687026 | 0.72 | TACR1 (0.60) | TACR1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100152446-A1 | Piperidine Derivatives | NERRE THERAPEUTICS LIMITED (GB) | 2010-06-17 | — | — | US | disclosed |
| US-7652012-B2 | Orvepitant maleate; potent and specific antagonists of tachykinins, including substance P and other neurokinins; anxioltic and antidepressant | GLAXO GROUP LIMITED (GB) | 2010-01-26 | — | — | US | disclosed |
| US-7482365-B2 | 4-(2,2-Dimethyl-propylamino)-2-(4-fluoro-2-methyl-phenyl)-piperidine-1-carboxylic acid, [1-(R)-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-methylamide; specific antagonists of tachykinins receptor: substance P and neurokinins (NK1); antidepressant, anxiolytic agent; serotonin receptor inhibitor | GLAXO GROUP LIMITED (GB) | 2009-01-27 | — | — | US | disclosed |
| EP-1666465-B1 | Composition comprising a tachykinin receptor antagonist and a selective serotonin reuptake inhibitor | GLAXO GROUP LTD (GB) | 2008-05-07 | — | — | EP | disclosed |
| CN-1319973-C | Piperidine derivatives | GLAXO GROUP LTD (GB) | 2007-06-06 | — | — | CN | disclosed |
| US-20070099914-A1 | Piperidine Derivatives | NERRE THERAPEUTICS LIMITED (GB) | 2007-05-03 | — | — | US | disclosed |
| US-7189713-B2 | Piperidine derivatives | GLAXO GROUP LIMITED (GB) | 2007-03-13 | — | — | US | disclosed |
| EP-1666465-A1 | Composition comprising a tachykinin receptor antagonist and a selective serotonin reuptake inhibitor | GLAXO GROUP LIMITED (GB) | 2006-06-07 | — | — | EP | disclosed |
| EP-1472256-B1 | PIPERIDINE DERIVATIVES | GLAXO GROUP LTD (GB) | 2005-11-02 | — | — | EP | disclosed |
| US-20050176715-A1 | Piperidine derivatives | NERRE THERAPEUTICS LIMITED (GB) | 2005-08-11 | — | — | US | disclosed |
| US-20050171153-A1 | Piperidylcarboxamide derivatives and their use in the treatment of tachykinin-mediated diseases | GLAXO GROUP LIMITED (GB) | 2005-08-04 | — | — | US | disclosed |
| CN-1628115-A | Piperidine derivatives | GLAXO GROUP LTD (GB) | 2005-06-15 | — | — | CN | disclosed |
| EP-1472256-A1 | PIPERIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003066635-A1 | PIPERIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2003-08-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050171153-A1 | Piperidylcarboxamide derivatives and their use in the treatment of tachykinin-mediated diseases | NPSR1, NPY1R, NPY2R | ALDH1A1 2635/4885TDP1 4295/4885MAPT 2288/4885 |
| US-20070099914-A1 | Piperidine Derivatives | PTGES2, NFKBIA, PTGS2 | ALDH1A1 332/4885TDP1 3255/4885MAPT 2632/4885 |
| US-20050176715-A1 | Piperidine derivatives | NPSR1, NPY5R, SSTR5 | ALDH1A1 4031/4885TDP1 4792/4885MAPT 4585/4885 |
| US-20100152446-A1 | Piperidine Derivatives | NPSR1, NPY5R, NPY4R | ALDH1A1 3922/4885TDP1 4779/4885MAPT 4616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.