Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | DNMT3B | Q9UBC3 | 2/20 | 0.43 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11002686 | 0.81 | AURKA (0.47) | KMOKDM4EALDH1A1POLBTGFBR1 | |
| SCHEMBL3080629 | 0.78 | MAPT (0.53) | KMOKDM4EALDH1A1POLBMAPT | |
| SCHEMBL1965714 | 0.77 | KDM4E (0.57) | KMOKDM4EALDH1A1POLBMAPT | |
| SCHEMBL3346124 | 0.77 | PIK3CB (0.67) | MAP4K4PIK3CBSIRT3TDP1MKNK1 | |
| SCHEMBL3346928 | 0.77 | SIRT3 (0.53) | SYKPIK3CBSIRT3TDP1MKNK1 | |
| Hydrochloric Acid SCHEMBL4630417 | 0.77 | MAPT (0.52) | KMOTGFBR1MAPTGSK3BDNMT3B | |
| SCHEMBL3342661 | 0.77 | TGFBR1 (0.46) | ALDH1A1TGFBR1MAP4K4GSK3BCAMKK2 | |
| SCHEMBL3342237 | 0.76 | KDM4E (0.53) | KMOKDM4EALDH1A1POLBMAPT | |
| SCHEMBL3342287 | 0.75 | MKNK2 (0.47) | ALDH1A1MAP4K4MAPTIRAK4SYK | |
| SCHEMBL3342845 | 0.75 | ABL1 (0.45) | GSK3BSYKPIK3CBSIRT3TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | ROCHE PALO ALTO LLC | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | P2RY1, P2RX6, P2RX3 | KMO 3322/4885KDM4E 2591/4885ALDH1A1 1506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.