Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 12/20 | 0.50 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.45 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8513552 | 0.88 | GPR119 (0.51) | GPR119CHRM4ACACB | |
| SCHEMBL3343984 | 0.81 | ACACB (0.52) | GPR119ACACB | |
| SCHEMBL3342687 | 0.81 | GPR119 (0.52) | GPR119ACACB | |
| SCHEMBL3341593 | 0.80 | GPR119 (0.51) | GPR119ACACB | |
| SCHEMBL12239173 | 0.80 | GPR119 (0.48) | GPR119ACACB | |
| SCHEMBL22860581 | 0.80 | HRH3 (0.57) | CHRM4CHRNB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL3178150 | 0.78 | GPR119 (0.54) | GPR119ACACB | |
| SCHEMBL22198920 | 0.78 | CHRM4 (0.55) | CHRM4CHRNB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL27855620 | 0.78 | AOC3 (0.51) | GPR119 | |
| SCHEMBL461236 | 0.77 | GPR119 (0.53) | GPR119ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2643311-A1 | BICYCLIC GPR119 MODULATORS | Lupin Limited (IN) | 2013-10-02 | — | — | EP | disclosed |
| WO-2012069917-A1 | BICYCLIC GPR119 MODULATORS | LUPIN LIMITED (IN) | 2012-05-31 | — | — | WO | disclosed |