Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 5/20 | 0.52 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3342687 | 0.89 | GPR119 (0.52) | ACACBGPR119ADRB2MEN1KMT2A | |
| SCHEMBL3341593 | 0.88 | GPR119 (0.51) | ACACBGPR119ADRB2MEN1KMT2A | |
| SCHEMBL8515468 | 0.81 | GPR119 (0.53) | ACACBGPR119 | |
| SCHEMBL11756971 | 0.80 | LMNA (0.61) | EPHX2POLBMAPT | |
| SCHEMBL24244916 | 0.80 | SCN1A (0.56) | ADRB2MEN1KMT2AEPHX2POLB | |
| SCHEMBL6135447 | 0.79 | ALDH1A1 (0.55) | ACACBKMT2AEPHX2POLBMAPT | |
| SCHEMBL6135044 | 0.78 | MAPT (0.51) | ACACBMEN1KMT2AEPHX2POLB | |
| SCHEMBL24880446 | 0.77 | HRH3 (0.47) | ACACBPOLBMAPTHRH3 | |
| SCHEMBL24881050 | 0.77 | ACACB (0.47) | ACACBPOLBMAPTHRH3 | |
| SCHEMBL24880761 | 0.77 | ACACB (0.47) | ACACBPOLBMAPTHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010048149-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |
| WO-2010048149-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |