Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NNMT | P40261 | 2/20 | 0.42 |
| ▸ | LDHA | P00338 | 2/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | LDHB | P07195 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 3/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3342952 | 0.82 | P2RX7 (0.46) | P2RX7PIK3CBSIRT3TDP1NNMT | |
| SCHEMBL3346810 | 0.81 | MKNK1 (0.52) | PIK3CBSIRT3TDP1NNMTMKNK1 | |
| SCHEMBL3346928 | 0.81 | SIRT3 (0.53) | ABL1PIK3CBSIRT3TDP1NNMT | |
| SCHEMBL3346188 | 0.78 | SIRT3 (0.45) | PIK3CBSIRT3TDP1NNMTLDHA | |
| SCHEMBL3466788 | 0.77 | CASP1 (0.50) | P2RX7NNMTMKNK1MKNK2SYK | |
| SCHEMBL3347858 | 0.77 | P2RX7 (0.44) | P2RX7PIK3CBSIRT3TDP1NNMT | |
| SCHEMBL3467721 | 0.76 | CASP1 (0.49) | P2RX7SIRT3TDP1PARP1KDM1A | |
| SCHEMBL3342851 | 0.76 | CYP11B1 (0.46) | ABL1TDP1KDM1A | |
| SCHEMBL3346124 | 0.75 | PIK3CB (0.67) | ABL1PIK3CBSIRT3TDP1MKNK1 | |
| SCHEMBL3346644 | 0.75 | CHEK2 (0.49) | P2RX7PIK3CBSIRT3TDP1NNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | ROCHE PALO ALTO LLC | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | P2RY1, P2RX6, P2RX3 | ABL1 2468/4885P2RX7 8/4885PIK3CB 3229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.