Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | KMO | O15229 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20156152 | 0.83 | ALDH1A1 (0.53) | CYP3A4ALDH1A1TSHRKMT2AMAPT | |
| SCHEMBL3342123 | 0.80 | RAB9A (0.42) | CYP3A4ALDH1A1TSHRKMT2AMAPT | |
| SCHEMBL20150182 | 0.78 | AAK1 (0.35) | CYP3A4ALDH1A1TSHRKMT2AMAPT | |
| SCHEMBL20092476 | 0.78 | ALDH1A1 (0.56) | CYP3A4ALDH1A1TSHRMAPK1KMT2A | |
| SCHEMBL3343394 | 0.78 | MKNK1 (0.47) | KMT2AMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14091695 | 0.78 | NPC1 (0.54) | ALDH1A1TSHRKMT2AMAPTNPC1 | |
| SCHEMBL12491752 | 0.77 | KEAP1 (0.58) | CYP3A4ALDH1A1TSHRMAPK1ESR2 | |
| SCHEMBL23154025 | 0.76 | GAA (0.33) | CYP3A4ALDH1A1TSHRKMT2AMAPT | |
| SCHEMBL20092249 | 0.76 | TYK2 (0.43) | MAPTGAA | |
| SCHEMBL23329066 | 0.75 | TMEM97 (0.44) | CYP3A4ALDH1A1KMT2AMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | ROCHE PALO ALTO LLC | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | P2RY1, P2RX6, P2RX3 | CYP3A4 1590/4885ALDH1A1 1506/4885TSHR 1051/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.