Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3343330 | 0.95 | LMNA (0.45) | LMNAKMT2AMEN1NPC1RAB9A | |
| SCHEMBL371180 | 0.79 | MAPK1 (0.37) | LMNAKMT2AKDM4EPOLBMAPK1 | |
| SCHEMBL6696149 | 0.74 | LMNA (0.48) | LMNAKMT2AMEN1NPC1RAB9A | |
| SCHEMBL9110061 | 0.73 | ALOX15 (0.38) | LMNAKMT2AMEN1NPC1RAB9A | |
| SCHEMBL6297621 | 0.72 | LMNA (0.49) | LMNAKMT2AMEN1NPC1RAB9A | |
| SCHEMBL5401319 | 0.70 | MGAM (0.44) | LMNAKMT2AALDH1A1GAASMN1; SMN2 | |
| SCHEMBL7956193 | 0.70 | LMNA (0.56) | LMNAKMT2AMEN1NPC1RAB9A | |
| SCHEMBL25664507 | 0.69 | GAA (0.57) | LMNAKMT2AKDM4EMAPK1ALDH1A1 | |
| SCHEMBL11066828 | 0.68 | MGAM (0.46) | LMNAKMT2AALDH1A1GAASMN1; SMN2 | |
| SCHEMBL7823939 | 0.68 | LMNA (0.57) | LMNAKMT2AMEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010039982-A1 | CRTH2 MODULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2010-04-08 | — | — | WO | disclosed |