Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346950 | 0.81 | TSHR (0.47) | TSHRHSD17B10RAB9AALDH1A1TDP1 | |
| SCHEMBL3344529 | 0.81 | PTGER4 (0.40) | TSHRHSD17B10ALDH1A1TDP1KDM4E | |
| SCHEMBL3348744 | 0.76 | TSHR (0.50) | TSHRHSD17B10RAB9AALDH1A1TDP1 | |
| SCHEMBL3342751 | 0.71 | KATNA1 (0.38) | TSHRHSD17B10RAB9AALDH1A1TDP1 | |
| SCHEMBL19914238 | 0.70 | ALDH1A1 (0.41) | TSHRHSD17B10ALDH1A1TDP1ALOX15 | |
| Hydrochloric Acid SCHEMBL19899573 | 0.69 | ALDH1A1 (0.41) | TSHRHSD17B10ALDH1A1TDP1ALOX15 | |
| SCHEMBL27007976 | 0.68 | SMN1; SMN2 (0.49) | TSHRALDH1A1TDP1ALOX15KDM4E | |
| SCHEMBL14557022 | 0.67 | GLA (0.46) | TSHRHSD17B10ALDH1A1TDP1ALOX15 | |
| SCHEMBL20181394 | 0.66 | APLNR (0.49) | TSHRRAB9AALDH1A1TDP1GLA | |
| SCHEMBL3348708 | 0.65 | SMN1; SMN2 (0.50) | TSHRHSD17B10RAB9AALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | ROCHE PALO ALTO LLC | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | P2RY1, P2RX6, P2RX3 | TSHR 1051/4885HSD17B10 4607/4885RAB9A 1850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.