Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3345216 | 0.88 | ALDH1A1 (0.47) | ALDH1A1KDM4EMAPK1ADORA2BHTR4 | |
| SCHEMBL3346862 | 0.86 | ALDH1A1 (0.39) | ALDH1A1KDM4EKMT2ASMN1; SMN2ADORA2B | |
| SCHEMBL3345297 | 0.81 | MAPT (0.54) | ALDH1A1KMT2ASMN1; SMN2MAPK1GAA | |
| SCHEMBL520843 | 0.80 | JAK2 (0.44) | ALDH1A1KDM4EKMT2ASMN1; SMN2GAA | |
| SCHEMBL520842 | 0.80 | JAK2 (0.44) | ALDH1A1KDM4EKMT2ASMN1; SMN2GAA | |
| SCHEMBL30018979 | 0.79 | ALDH1A1 (0.50) | ALDH1A1KDM4ESMN1; SMN2MAPK1GAA | |
| SCHEMBL12714785 | 0.79 | ALDH1A1 (0.50) | ALDH1A1KDM4ESMN1; SMN2MAPK1GAA | |
| SCHEMBL3346988 | 0.77 | KDM4E (0.39) | ALDH1A1KDM4EKMT2ASMN1; SMN2MAPK1 | |
| SCHEMBL27046957 | 0.76 | HTR3E (0.51) | ALDH1A1KDM4EGAAMAPTLMNA | |
| SCHEMBL20591936 | 0.76 | ALDH1A1 (0.48) | ALDH1A1KDM4EMAPK1GAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |