Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2726089 | 0.79 | ALDH1A1 (0.48) | KDM4EALDH1A1MAPTCYP3A4MAPK1 | |
| SCHEMBL3344767 | 0.77 | ALDH1A1 (0.39) | KDM4EALDH1A1MAPTCYP1A2CYP2C19 | |
| SCHEMBL3315825 | 0.76 | CASP6 (0.49) | MAPTLMNA | |
| SCHEMBL2229043 | 0.76 | ADAMTS5 (0.42) | CCR1ADAMTS4ADAMTS5KMT2A | |
| SCHEMBL30336390 | 0.74 | MAPT (0.40) | KDM4EALDH1A1MAPTMAPK1LMNA | |
| SCHEMBL4016287 | 0.74 | CCR1 (0.55) | ALDH1A1MAPTCYP2C19LMNACCR1 | |
| SCHEMBL3345216 | 0.72 | ALDH1A1 (0.47) | KDM4EALDH1A1MAPTMAPK1HTR4 | |
| SCHEMBL5077254 | 0.71 | GAA (0.46) | KDM4EMAPTDRD2DRD4SMN1; SMN2 | |
| SCHEMBL20591936 | 0.71 | ALDH1A1 (0.48) | KDM4EALDH1A1MAPTMAPK1DRD2 | |
| SCHEMBL10075922 | 0.71 | HTR7 (0.50) | KDM4EALDH1A1DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |