Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MPI | P34949 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | COMT | P21964 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2706312 | 0.77 | HSP90AA1 (0.58) | KDM4EL3MBTL1MEN1KMT2ATDP1 | |
| SCHEMBL11926273 | 0.77 | HTT (0.46) | KDM4EL3MBTL1MEN1KMT2ATDP1 | |
| SCHEMBL10883279 | 0.73 | KDM4E (0.39) | KDM4EL3MBTL1MEN1KMT2ATDP1 | |
| SCHEMBL11170566 | 0.73 | KDM4E (0.54) | KDM4EL3MBTL1MEN1KMT2ATDP1 | |
| SCHEMBL30818296 | 0.73 | KCNMA1 (0.41) | KDM4EMEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL11926120 | 0.73 | COMT (0.40) | KDM4EL3MBTL1MEN1KMT2AALDH1A1 | |
| SCHEMBL6643350 | 0.73 | KCNMA1 (0.41) | KDM4EMEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL3249138 | 0.73 | ALDH1A1 (0.58) | KDM4EL3MBTL1TDP1ALDH1A1LMNA | |
| SCHEMBL12663631 | 0.73 | KDM4E (0.50) | KDM4EL3MBTL1MEN1KMT2ATDP1 | |
| SCHEMBL27736187 | 0.73 | KDM4E (0.39) | KDM4EL3MBTL1MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010045987-A1 | SUBSTITUTED (AZA) -1-METHYL-1H-QUIN0LIN-2-0NES AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2010-04-29 | — | — | WO | disclosed |
| WO-2010046388-A1 | SUBSTITUTED (AZA) -1-METHYL-1H-QUINOLIN-2-ONES AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2010-04-29 | — | — | WO | disclosed |