Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.39 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.39 |
| ▸ | PLA2G2E | Q9NZK7 | 2/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | WDR5 | P61964 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3349098 | 0.90 | ALDH1A1 (0.44) | TDP1TSHRLMNARXFP1MAPT | |
| SCHEMBL3346252 | 0.89 | PLA2G2A (0.44) | TDP1TSHRLMNAPLA2G10PLA2G1B | |
| SCHEMBL3345066 | 0.88 | TDP1 (0.43) | TDP1TSHRMAPTPLA2G10PLA2G1B | |
| SCHEMBL3348093 | 0.85 | PLA2G2A (0.45) | TDP1TSHRPLA2G10PLA2G1BPLA2G2A | |
| SCHEMBL3346104 | 0.84 | PLA2G10 (0.41) | TDP1TSHRPLA2G10PLA2G1BPLA2G2A | |
| SCHEMBL3344022 | 0.83 | PLA2G1B (0.49) | MAPTPLA2G10PLA2G1BPLA2G2APLA2G5 | |
| SCHEMBL3345067 | 0.81 | PPARG (0.42) | TDP1TSHRMAPTPPARDPTGDR2 | |
| SCHEMBL3346049 | 0.80 | PLA2G2A (0.41) | MAPTPLA2G10PLA2G1BPLA2G2APLA2G5 | |
| SCHEMBL3346068 | 0.80 | TDP1 (0.43) | TDP1TSHRRXFP1PLA2G10PLA2G1B | |
| SCHEMBL3345105 | 0.80 | ALDH1A1 (0.45) | TDP1TSHRLMNARXFP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | disclosed |
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | disclosed |