Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 4/20 | 0.41 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.41 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.41 |
| ▸ | PLA2G2E | Q9NZK7 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3344022 | 0.91 | PLA2G1B (0.49) | PLA2G2APLA2G10PLA2G1BPLA2G5PLA2G2E | |
| SCHEMBL3345142 | 0.90 | ALDH1A1 (0.45) | PLA2G2ABRD4TRPC5ALDH1A1KDM4E | |
| SCHEMBL3345066 | 0.90 | TDP1 (0.43) | PLA2G2APLA2G10PLA2G1BPLA2G5PLA2G2E | |
| SCHEMBL3346104 | 0.86 | PLA2G10 (0.41) | PLA2G2APLA2G10PLA2G1BPLA2G5PLA2G2E | |
| SCHEMBL3348093 | 0.83 | PLA2G2A (0.45) | PLA2G2APLA2G10PLA2G1BPLA2G5PLA2G2E | |
| SCHEMBL3345145 | 0.82 | PTGDR2 (0.41) | PLA2G2APLA2G10PLA2G1BPLA2G5PLA2G2E | |
| SCHEMBL3345067 | 0.82 | PPARG (0.42) | TRPC5THRATHRBMAPTPKM | |
| SCHEMBL3346068 | 0.82 | TDP1 (0.43) | PLA2G2APLA2G10PLA2G1BPLA2G5PLA2G2E | |
| SCHEMBL3344698 | 0.81 | AKR1B1 (0.43) | KDM4EMAPTPTGDR2 | |
| SCHEMBL3346252 | 0.81 | PLA2G2A (0.44) | PLA2G2APLA2G10PLA2G1BPLA2G5PLA2G2E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | claimed |
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | disclosed |
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | disclosed |